Melanoma is the most aggressive form of skin cancer that is known for its metastatic potential and has an increasing incidence worldwide. Breslow thickness, which determines the staging and surgical margin of the tumor, is unavailable at initial diagnosis. Novel imaging techniques for assessing Breslow thickness lack comparative data. This study evaluates optically guided high-frequency ultrasound (OG-HFUS) and multispectral imaging (MSI) for preoperative estimation of Breslow thickness and staging. We enrolled 101 patients with histologically confirmed primary melanoma and categorized them based on tumor thickness. Optically guided 33 MHz HFUS and MSI were utilized for the assessment. Our MSI-based algorithm categorized melanomas into three subgroups with a sensitivity of 62.6%, specificity of 81.3%, and fair agreement (κ = 0.440, CI: 0.298–0.583). In contrast, OG-HFUS demonstrated a sensitivity of 91.8%, specificity of 96.0%, and almost perfect agreement (κ = 0.858, CI: 0.763–0.952). OG-HFUS performed better than MSI in estimating Breslow thickness, emphasizing its potential as a valuable tool for melanoma diagnosis and patient management. OG-HFUS holds promise for enhancing preoperative staging and treatment decision-making in melanoma.
黑色素瘤是最具侵袭性的皮肤癌类型，以其转移潜能和全球范围内不断上升的发病率而备受关注。决定肿瘤分期和手术切缘的Breslow厚度在初次诊断时无法获取，而评估该厚度的新型影像技术尚缺乏对比数据。本研究评估了光学引导高频超声（OG-HFUS）与多光谱成像（MSI）在术前评估Breslow厚度及分期中的应用价值。我们纳入了101例经组织学确诊的原发性黑色素瘤患者，并根据肿瘤厚度进行分组。采用光学引导33 MHz高频超声和多光谱成像技术进行评估。基于MSI的算法将黑色素瘤分为三个亚组，其敏感性为62.6%，特异性为81.3%，一致性中等（κ=0.440，CI：0.298-0.583）。相比之下，OG-HFUS表现出91.8%的敏感性、96.0%的特异性，且一致性近乎完美（κ=0.858，CI：0.763-0.952）。在评估Breslow厚度方面，OG-HFUS的表现优于MSI，凸显了其作为黑色素瘤诊断和患者管理重要工具的潜力。OG-HFUS有望提升黑色素瘤的术前分期和治疗决策水平。
肿瘤(癌症)患者之家