Despite recent(最近) improvements in diagnostic ability(能力) and treatment(治疗) strategies for patients(病人) with neoplastic disease(疾病), gastrointestinal (GI) cancers(癌症), such(这样) as colorectal, gastric, pancreatic, and oesophageal cancers(癌症), are still common(常见) malignancies and the leading(领先) cause(原因) of cancer(癌症) deaths worldwide(全世界), with a high frequency of recurrence and metastasis as well as poor patient(病人) prognosis. There is a link(链接) between the secretion of proteolytic enzymes that degrade the extracellular matrix and the pathogenesis of GI tumours. Recent(最近) findings have focused(焦点) on the potential(潜在) significance(意义) of selected claudins (CLDNs) in the pathogenesis and prognosis of GI cancers(癌症). Tight junctions (TJs) have been proven to play an important role(作用) in maintaining cell(细胞) polarity and permeability. A number of authors have recently(最近) revealed that TJ proteins, particularly(特别是) selected CLDNs, are related(相关) to inflammation and the development(发展) of various tumours, including GI malignancies. This review(检讨) presents general(一般) characteristics and the involvement(参与) of selected CLDNs in the progression(进展) of GI malignancies, with a focus(焦点) on the potential(潜在) application(应用) of these proteins in the diagnosis(诊断) and prognosis of colorectal cancer(癌症) (CRC), gastric cancer(癌症) (GC), pancreatic cancer(癌症) (PC), and oesophageal cancer(癌症) (EC). Our review(检讨) indicates that selected CLDNs, particularly(特别是) CLDN1, 2, 4, 7, and 18, play a significant(显著) role(作用) in the development(发展) of GI tumours and in patient(病人) prognosis. Furthermore, selected CLDNs may be of value(价值) in the design(设计) of therapeutic(治疗) strategies for the treatment(治疗) of recurrent tumours.
尽管近年来对肿瘤患者的诊断能力和治疗策略有所改进，但结直肠癌、胃癌、胰腺癌和食管癌等胃肠道癌症仍然是常见的恶性肿瘤，也是全球癌症死亡的主要原因，其复发和转移频率高，患者预后较差。降解细胞外基质的蛋白水解酶的分泌与胃肠道肿瘤的发病机制之间存在关联。最近的研究发现集中在特定紧密连接蛋白（CLDNs）在胃肠道癌症发病机制和预后中的潜在意义。紧密连接已被证实在维持细胞极性和渗透性方面发挥重要作用。一些作者最近揭示，紧密连接蛋白，特别是特定的CLDNs，与炎症及包括胃肠道恶性肿瘤在内的多种肿瘤的发展相关。本综述介绍了特定CLDNs的一般特性及其在胃肠道恶性肿瘤进展中的参与，重点探讨了这些蛋白在结直肠癌、胃癌、胰腺癌和食管癌的诊断和预后中的潜在应用。我们的综述表明，特定的CLDNs，特别是CLDN1、2、4、7和18，在胃肠道肿瘤的发展和患者预后中发挥重要作用。此外，特定的CLDNs可能在设计治疗复发性肿瘤的治疗策略中具有价值。
Claudins—Promising Biomarkers for Selected Gastrointestinal (GI) Malignancies?
肿瘤(癌症)患者之家