Mucinous (colloid) adenocarcinomas (MAs) are a rare histological subtype of tumors defined by extracellular mucin comprising more than 50% of the tumor. These tumors are on a continuum of mucin-producing malignancies with signet ring cell adenocarcinomas (SRCCs), which instead produce intracellular mucin. Mucin-containing cancers occur primarily in the stomach and colon, where for SRCCs, outcomes are relatively worse in the proximal stomach and the rectum. It is not known if MAs have similar outcomes. In this study, we use the Surveillance, Epidemiology, and End Results (SEER) database to examine the effects of tumor localization, age, sex, and stage on colorectal and gastric cancer outcomes for MAs. For right colon cancers, MAs are more common, particularly in females, and have slightly better or equivalent outcomes across all stages and ages compared to conventional adenocarcinomas, but outcomes are progressively worse compared to conventional adenocarcinomas for left colon and rectal cancers. Unlike SRCCs, MAs have similar outcomes to conventional adenocarcinomas in all stomach locations. Overall, these results suggest that MAs have an intrinsically different tumor biology in the left colon and rectum that promotes pathogenesis. Decoding this phenomenon could lead to more effectively tailored patient treatment regimens.
黏液性（胶样）腺癌是一种罕见的组织学亚型肿瘤，其定义为细胞外黏液占肿瘤体积50%以上。这类肿瘤与印戒细胞腺癌同属黏液分泌型恶性肿瘤谱系，后者主要产生细胞内黏液。含黏液成分的癌症主要发生于胃和结肠，其中印戒细胞腺癌在近端胃和直肠的预后相对较差，而黏液性腺癌是否具有相似预后特征尚不明确。本研究利用美国监测、流行病学和最终结果数据库，系统分析了肿瘤定位、年龄、性别及分期对结直肠和胃癌黏液性腺癌预后的影响。研究发现：在右半结肠癌中，黏液性腺癌更为常见（尤其女性患者），且在各分期和年龄组中较传统腺癌具有略优或相当的预后；但在左半结肠和直肠癌中，其预后较传统腺癌呈进行性恶化趋势。与印戒细胞腺癌不同，黏液性腺癌在所有胃部定位中均与传统腺癌预后相似。总体而言，这些结果表明黏液性腺癌在左半结肠和直肠区域具有独特的肿瘤生物学特性，可能促进其病理发生机制。解析这一现象有望为患者制定更精准有效的个体化治疗方案。
Location Has Prognostic Impact on the Outcome of Colorectal Mucinous Adenocarcinomas
肿瘤(癌症)患者之家