We conducted a single-center, non-interventional retrospective study of melanoma patients with COVID-19 (1 March 2020 until 17 March 2023). The cohort was further divided into three groups according to the periods of SARS-CoV-2 variant dominance in Greece. We recorded demographics, comorbidities, vaccination data, cancer diagnosis/stage, types of systemic melanoma treatments, date of COVID-19 diagnosis and survival. We identified 121 patients. The vast majority (87.6%) had advanced disease (stages III or IV). A total of 80.1% of the patients were receiving immune checkpoint inhibitor-based therapies, 92.5% had asymptomatic/mild COVID-19 and 7.4% had moderate/severe/critical disease, while 83.5% contracted COVID-19 during the third period of the pandemic. Sixteen patients (13.2%) were hospitalized for COVID-19 with a median length of stay of 12 days (range: 1–55 days). Advanced age, heart failure, number of comorbidities (≤1 vs. >1), vaccination status and the time period of the infection correlated with more severe COVID-19, whereas only heart failure and time period were independently correlated with severity. The 30-day mortality rate after COVID-19 was 4.2%. With a median follow-up of 340 days post-COVID-19, 17.4% of patients were deceased. In this cohort of melanoma patients with COVID-19, the 30-day mortality rate was low. There was no association between melanoma stage, treatment receipt and type of treatment with COVID-19 severity.
我们对2020年3月1日至2023年3月17日期间确诊COVID-19的黑色素瘤患者开展了一项单中心、非干预性回顾性研究。根据希腊境内SARS-CoV-2变异株流行时段，将队列进一步划分为三个亚组。研究记录了人口统计学特征、合并症、疫苗接种数据、癌症诊断/分期、系统性黑色素瘤治疗方案类型、COVID-19确诊日期及生存状况。共纳入121例患者，绝大多数（87.6%）处于晚期（III期或IV期）。80.1%的患者正在接受基于免疫检查点抑制剂的治疗方案，92.5%表现为无症状/轻型COVID-19感染，7.4%为中度/重度/危重型感染，其中83.5%的感染发生在疫情第三阶段。16例患者（13.2%）因COVID-19住院，中位住院时间为12天（范围：1-55天）。高龄、心力衰竭、合并症数量（≤1项对比>1项）、疫苗接种状态及感染时段与更严重的COVID-19病情相关，而仅心力衰竭和感染时段与疾病严重程度存在独立相关性。COVID-19感染后30天死亡率为4.2%。在感染后中位随访340天期间，总死亡率为17.4%。本研究表明，COVID-19感染的黑色素瘤患者队列30天死亡率较低，黑色素瘤分期、治疗接受情况及治疗方案类型与COVID-19严重程度无显著关联。
COVID-19 in Patients with Melanoma: A Single-Institution Study
肿瘤(癌症)患者之家