文章：

细胞外信号调节激酶：一条通路，多重命运

Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates

原文发布日期：24 December 2023

DOI: 10.3390/cancers16010095

类型: Article

开放获取: 是

英文摘要：

This comprehensive review delves into the multifaceted aspects of ERK signaling and the intricate mechanisms underlying distinct cellular fates. ERK1 and ERK2 (ERK) govern proliferation, transformation, epithelial–mesenchymal transition, differentiation, senescence, or cell death, contingent upon activation strength, duration, and context. The biochemical mechanisms underlying these outcomes are inadequately understood, shaped by signaling feedback and the spatial localization of ERK activation. Generally, ERK activation aligns with the Goldilocks principle in cell fate determination. Inadequate or excessive ERK activity hinders cell proliferation, while balanced activation promotes both cell proliferation and survival. Unraveling the intricacies of how the degree of ERK activation dictates cell fate requires deciphering mechanisms encompassing protein stability, transcription factors downstream of ERK, and the chromatin landscape.

摘要翻译： 

本综述深入探讨了ERK信号通路的多维层面及其调控不同细胞命运的复杂机制。ERK1和ERK2（统称ERK）根据激活强度、持续时间和细胞环境的不同，可分别调控细胞增殖、转化、上皮-间质转化、分化、衰老或死亡。这些结果背后的生化机制尚未被充分理解，其形成受到信号反馈和ERK激活空间定位的影响。总体而言，ERK激活在细胞命运决定中遵循"金发姑娘原则"：活性不足或过度均会抑制细胞增殖，而适度激活则能促进细胞增殖与存活。要阐明ERK激活程度决定细胞命运的具体机制，需要从蛋白质稳定性、ERK下游转录因子及染色质景观等多个维度进行系统性解析。

原文链接：

Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates