Objectives: Pancreatic cancer (PC) surveillance of high-risk individuals (HRIs) downstages PC and improves survival. However, it remains less clear whether PC surveillance has a positive psychosocial impact on HRIs. Herein, we aimed to define the attitudes and beliefs of HRIs undergoing PC surveillance, and the immediate and sustained psychosocial impact of PC surveillance in HRIs. Methods: 100 HRIs undergoing PC surveillance by endoscopic ultrasound (EUS) completed three surveys addressing different components of the psychosocial impact of PC surveillance. Logistic regression analyses were performed to identify predictive factors relating to these components. Results: Most HRIs reported increased perceived benefits of PC surveillance, self-efficacy, and perceived severity of PC. HRIs reported few negative emotions prior to surveillance and frequent positive emotions after surveillance. Compared to prior to surveillance, there was a 53.5% decrease in the level of distress reported by HRIs after surveillance, which was sustained for 4–6 weeks post-surveillance. Family history of PC and lower self-reported mental health were identified as predictors for increased perceived susceptibility to PC (p< 0.01) and greater change in distress pre- to post-surveillance (p< 0.01), respectively. Conclusions: Our findings suggest that PC surveillance can lead to sustained psychosocial benefits in HRIs.
目的：对高危个体（HRIs）进行胰腺癌（PC）监测可降低PC分期并提高生存率。然而，PC监测是否对HRIs产生积极的心理社会影响尚不明确。本研究旨在明确接受PC监测的HRIs的态度和信念，以及PC监测对HRIs产生的即时和持续的心理社会影响。方法：100名通过超声内镜（EUS）接受PC监测的HRIs完成了三份调查问卷，评估PC监测心理社会影响的不同方面。采用逻辑回归分析确定与这些方面相关的预测因素。结果：大多数HRIs报告PC监测的感知益处、自我效能感以及对PC严重程度的认知均有所提高。HRIs在监测前报告的负面情绪较少，而在监测后报告了频繁的积极情绪。与监测前相比，监测后HRIs报告的心理困扰水平降低了53.5%，且这种改善在监测后持续了4-6周。PC家族史和较低的自评心理健康水平分别被确定为预测PC感知易感性增加（p<0.01）以及监测前后心理困扰变化更大（p<0.01）的因素。结论：我们的研究结果表明，PC监测可为HRIs带来持续的心理社会益处。
Assessment of the Psychosocial Impact of Pancreatic Cancer Surveillance in High-Risk Individuals
肿瘤(癌症)患者之家