Striatins (STRNs) are generally considered to be cytoplasmic proteins, with lower expression observed in the nucleus and at cell–cell contact regions. Together with protein phosphatase 2A (PP2A), STRNs form the core region of striatin-interacting phosphatase and kinase (STRIPAK) complexes through the coiled-coil region of STRN proteins, which is crucial for substrate recruitment. Over the past two decades, there has been an increasing amount of research into the biological and cellular functions of STRIPAK members. STRNs and the constituent members of the STRIPAK complex have been found to regulate several cellular functions, such as cell cycle control, cell growth, and motility. Dysregulation of these cellular events is associated with cancer development. Importantly, their roles in cancer cells and clinical cancers are becoming recognised, with several STRIPAK components found to have elevated expression in cancerous tissues compared to healthy tissues. These molecules exhibit significant diagnostic and prognostic value across different cancer types and in metastatic progression. The present review comprehensively summarises and discusses the current knowledge of STRNs and core STRIPAK members, in cancer malignancy, from both cellular and clinical perspectives.
纹蛋白（STRNs）通常被认为是胞质蛋白，在细胞核及细胞间接触区域表达较低。通过与蛋白磷酸酶2A（PP2A）结合，纹蛋白通过其卷曲螺旋结构域形成纹蛋白相互作用磷酸酶与激酶（STRIPAK）复合体的核心区域，这一结构对底物募集至关重要。近二十年来，关于STRIPAK成员生物学及细胞功能的研究日益增多。研究发现纹蛋白及其组成的STRIPAK复合体成员可调控多种细胞功能，包括细胞周期控制、细胞生长与运动等。这些细胞活动的失调与癌症发展密切相关。值得注意的是，这些分子在癌细胞及临床癌症中的作用正逐渐被认识，多项研究表明多个STRIPAK组分在癌组织中表达水平显著高于正常组织。这些分子在不同癌症类型及转移进展中展现出重要的诊断与预后价值。本综述从细胞生物学与临床医学双重视角，系统总结并探讨了当前关于纹蛋白及核心STRIPAK成员在癌症恶性进展中的研究认知。
肿瘤(癌症)患者之家