Patients with ovarian cancer (OC) often experience anxiety, depression and fear of progression (FOP); however, it is unclear whether surgical complexity has a role to play. We investigated the prevalence of anxiety, depression and FOP at 12 months post-cytoreductive surgery and investigated associations with surgical complexity, patient (age, ethnicity, performance status, BMI) and tumour (stage, disease load) factors. One hundred and forty-one patients with FIGO Stage III–IV OC, who did not have disease progression at 12 months post-surgery, completed the Hospital Anxiety and Depression Scale and FOP short-form questionnaire. Patients underwent surgery with low (40.4%), intermediate (31.2%) and high (28.4%) surgical complexity scores. At 12 months post-surgery, 99 of 141 (70%) patients with advanced OC undergoing surgery experienced clinically significant anxiety, 21 of 141 (14.9%) patients experienced moderate to severe depression and 37 of 140 (26.4%) experienced dysfunctional FOP. No associations were identified between the three different surgical complexity groups with regards to anxiety, depression or FOP scores. Unsurprisingly, given the natural history of the disease, most patients with OC suffer from anxiety, depression and fear of progression after completion of first-line cancer treatment. Surgical complexity at the time of surgery is not associated with a deleterious impact on anxiety, depression or FOP for patients with OC. Patients with OC experience a profound mental health impact and should be offered mental health support throughout their cancer journey.
卵巢癌患者常伴有焦虑、抑郁及疾病进展恐惧等心理问题，但手术复杂程度是否对此产生影响尚不明确。本研究调查了肿瘤细胞减灭术后12个月时患者焦虑、抑郁及疾病进展恐惧的发生率，并分析其与手术复杂程度、患者因素（年龄、种族、体能状态、体重指数）及肿瘤特征（分期、病灶负荷）的关联性。141例国际妇产科联盟III-IV期卵巢癌患者（术后12个月无疾病进展）完成了医院焦虑抑郁量表和疾病进展恐惧简化量表评估。患者手术复杂程度评分显示：低复杂度占40.4%，中复杂度占31.2%，高复杂度占28.4%。术后12个月数据显示：接受手术的晚期卵巢癌患者中，70%（99/141）出现临床显著焦虑，14.9%（21/141）存在中重度抑郁，26.4%（37/140）呈现功能失调性疾病进展恐惧。三种不同手术复杂程度组别在焦虑、抑郁或疾病进展恐惧评分方面均未发现显著关联。鉴于疾病自然病程特点，多数卵巢癌患者在一线治疗结束后出现焦虑、抑郁及疾病进展恐惧的现象并不意外。研究证实手术复杂程度不会对卵巢癌患者的焦虑、抑郁或疾病进展恐惧产生负面影响。卵巢癌患者承受着显著的心理健康冲击，应在整个诊疗过程中获得系统的心理健康支持。
肿瘤(癌症)患者之家