文章：

美国COVID-19大流行期间乳腺癌患者的经济负担研究

Financial Toxicity among Patients with Breast Cancer during the COVID-19 Pandemic in the United States

原文发布日期：21 December 2023

DOI: 10.3390/cancers16010062

类型: Article

开放获取: 是

英文摘要：

This study reported the prevalence of financial distress (financial toxicity (FT)) and COVID-19-related economic stress in patients with breast cancer (BC). Patients with BC were recruited from the Ciitizen platform, Breastcancer.org, and patient advocacy groups between 30 March and 6 July 2021. FT was assessed with the COmprehensive Score for financial Toxicity (COST) instrument. COVID-19-related economic stress was assessed with the COVID-19 Stress Scale. Among the 669 patients, the mean age was 51.6 years; 9.4% reported a COVID-19 diagnosis. The prevalence rates of mild and moderate/severe FT were 36.8% and 22.4%, respectively. FT was more prevalent in patients with metastatic versus early BC (p< 0.001). The factors associated with FT included income ≤ USD 49,999 (adjusted odds ratio (adj OR) 6.271,p< 0.0001) and USD 50,000–USD 149,999 (adj OR 2.722,p< 0.0001); aged <50 years (adj OR 3.061,p= 0.0012) and 50–64 years (adj OR 3.444,p= 0.0002); living alone (adj OR 1.603,p= 0.0476); and greater depression severity (adj OR 1.155,p< 0.0001). Black patients (adj OR 2.165,p= 0.0133), patients with income ≤ USD 49,999 (adj OR 1.921,p= 0.0432), or greater depression severity (adj OR 1.090,p< 0.0001) were more likely to experience COVID-19-related economic stress. FT was common in patients with BC, particularly metastatic disease, during COVID-19. Multiple factors, especially lower income and greater depression severity were associated with financial difficulties during COVID-19.

摘要翻译： 

本研究旨在报告乳腺癌患者中财务困境（财务毒性）及与COVID-19相关的经济压力的普遍性。研究于2021年3月30日至7月6日期间，通过Ciitizen平台、Breastcancer.org及患者倡导团体招募乳腺癌患者。财务毒性采用综合财务毒性评分量表进行评估，COVID-19相关经济压力则通过COVID-19压力量表进行测量。在669名患者中，平均年龄为51.6岁；9.4%的患者报告确诊COVID-19。轻度及中度/重度财务毒性的患病率分别为36.8%和22.4%。与早期乳腺癌患者相比，转移性乳腺癌患者的财务毒性更为普遍（p<0.001）。与财务毒性相关的因素包括：年收入≤49,999美元（调整后比值比6.271，p<0.0001）及50,000–149,999美元（调整后比值比2.722，p<0.0001）；年龄<50岁（调整后比值比3.061，p=0.0012）及50–64岁（调整后比值比3.444，p=0.0002）；独居（调整后比值比1.603，p=0.0476）；以及更严重的抑郁症状（调整后比值比1.155，p<0.0001）。黑人患者（调整后比值比2.165，p=0.0133）、年收入≤49,999美元的患者（调整后比值比1.921，p=0.0432）或抑郁症状更严重的患者（调整后比值比1.090，p<0.0001）更可能经历COVID-19相关的经济压力。在COVID-19疫情期间，财务毒性在乳腺癌患者中较为常见，尤其是转移性疾病患者。多种因素，特别是较低收入和更严重的抑郁症状，与疫情期间的财务困难相关。

原文链接：

Financial Toxicity among Patients with Breast Cancer during the COVID-19 Pandemic in the United States