Gastric cancer (GC) is one of the most common malignancies worldwide. There has been no efficient therapy for stage IV GC patients due to this disease’s heterogeneity and dissemination ability. Despite the rapid advancement of molecular targeted therapies, such as HER2 and immune checkpoint inhibitors, survival of GC patients is still unsatisfactory because the understanding of the mechanism of GC progression is still incomplete. Invasion is the most important feature of GC metastasis, which causes poor mortality in patients. Recently, genomic research has critically deepened our knowledge of which gene products are dysregulated in invasive GC. Furthermore, the study of the interaction of GC cells with the tumor microenvironment has emerged as a principal subject in driving invasion and metastasis. These results are expected to provide a profound knowledge of how biological molecules are implicated in GC development. This review summarizes the advances in our current understanding of the molecular mechanism of GC invasion. We also highlight the future directions of the invasion therapeutics of GC. Compared to conventional therapy using protease or molecular inhibitors alone, multi-therapy targeting invasion plasticity may seem to be an assuring direction for the progression of novel strategies.
胃癌是全球范围内最常见的恶性肿瘤之一。由于该疾病的异质性和播散能力，目前针对IV期胃癌患者尚无有效疗法。尽管分子靶向治疗（如HER2抑制剂和免疫检查点抑制剂）发展迅速，但由于对胃癌进展机制的认识仍不全面，患者的生存状况仍不理想。侵袭是胃癌转移最重要的特征，也是导致患者高死亡率的主要原因。近期基因组学研究显著深化了我们对侵袭性胃癌中基因产物失调的认识。此外，胃癌细胞与肿瘤微环境的相互作用研究已成为驱动侵袭和转移机制的核心课题。这些研究成果有望为揭示生物分子在胃癌发展中的作用机制提供深刻见解。本综述总结了当前对胃癌侵袭分子机制认识的进展，并着重探讨了未来胃癌侵袭治疗的研究方向。相较于传统单一使用蛋白酶抑制剂或分子抑制剂的疗法，针对侵袭可塑性的多靶点联合治疗策略可能成为新型治疗方案发展的可靠方向。
Molecular Insight into Gastric Cancer Invasion—Current Status and Future Directions
肿瘤(癌症)患者之家