Squamous cell carcinoma of the nasal vestibule is considered a rare malignancy that differs from other sinonasal malignancies in many respects. Four staging systems currently exist for this disease, the most recent addition being the “Rome” classification. This study assesses the use of this new classification and its prognostic value regarding various outcome measures. A retrospective multicenter cohort study of patients with a primary squamous cell carcinoma of the nasal vestibule who were treated in three tertiary head and neck oncology referral centers was conducted. A total of 149 patients were included. The median follow-up duration was 27 months. Five-year locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS) were 81.6%, 90.1, and 62.5% respectively. A statistically significant association was observed between the Rome classification and all survival outcomes in both univariable and multivariable analyses. Moreover, it appeared to perform better than the Union for International Cancer Control TNM classification for tumors of the nasal cavity and paranasal sinuses. The new Rome classification can be used effectively and is associated with LRC, DSS, and OS. However, it requires further validation in a larger (prospective) study population.
鼻前庭鳞状细胞癌是一种罕见的恶性肿瘤，其特点与其它鼻腔鼻窦恶性肿瘤存在多方面差异。目前针对该疾病存在四种分期系统，其中最新提出的为"罗马"分类法。本研究旨在评估这一新分类系统的临床应用价值及其对不同预后指标的预测效能。研究采用回顾性多中心队列设计，纳入三家三级头颈肿瘤转诊中心收治的原发性鼻前庭鳞状细胞癌患者，共计149例，中位随访时间为27个月。五年局部区域控制率、疾病特异性生存率和总生存率分别为81.6%、90.1%和62.5%。单变量与多变量分析均显示罗马分类与所有生存结局存在统计学显著关联，且相较于国际抗癌联盟鼻腔鼻窦肿瘤TNM分期系统表现出更优的预测性能。新的罗马分类系统具有临床适用性，能够有效预测局部区域控制率、疾病特异性生存率和总生存率，但尚需在更大规模（前瞻性）研究人群中进一步验证。
Validation of the “Rome” Classification for Squamous Cell Carcinoma of the Nasal Vestibule
肿瘤(癌症)患者之家