Cervical cancer is associated with persistent Human Papilloma Virus (HPV) infections and is the fourth most common cancer in women worldwide. Current treatment options; surgery, chemotherapy, and radiation, are often associated with severe side effects including possible infertility. Novel treatment options are required to help combat this disease and reduce side effects. Many plant-derived chemicals, including paclitaxel and docetaxel, are already in use as treatments for various cancers. Genistein is a polyphenolic isoflavone found in foods including soybeans and legumes, and studies have shown that it has various biological effects and anti-cancer properties. This review aims to summarize the existing studies examining the effects of genistein on cervical cancer. All relevant in vitro and in vivo studies are summarized, and the key findings are highlighted in the associated tables. Based on the available in vitro/cell culture studies reported here, genistein inhibits cervical cancer cell proliferation and induces apoptosis. Use of genistein in combination with radiation or chemotherapy agents resulted in enhanced response indicating radio- and chemo-sensitization properties. More animal studies are required to examine the effectiveness of genistein in vivo. Such studies will form the basis for future human studies exploring the potential of genistein to be used in the treatment of cervical cancer.
宫颈癌与持续感染人乳头瘤病毒（HPV）相关，是全球女性第四大常见癌症。目前的手术、化疗和放疗等治疗方案常伴随严重副作用，包括可能导致不孕。需要开发新型治疗方法以对抗该疾病并减少副作用。包括紫杉醇和多西他赛在内的多种植物源化学物质已被用于治疗多种癌症。染料木黄酮是一种存在于大豆和豆类等食物中的多酚类异黄酮，研究表明其具有多种生物效应和抗癌特性。本综述旨在总结现有关于染料木黄酮对宫颈癌作用的研究，汇总所有相关体外和体内实验，并在相应表格中突出关键发现。基于现有报道的体外/细胞培养研究，染料木黄酮能抑制宫颈癌细胞增殖并诱导细胞凋亡。染料木黄酮与放疗或化疗药物联用可增强疗效，表明其具有放射增敏和化学增敏特性。未来需要更多动物实验验证染料木黄酮的体内有效性，此类研究将为探索染料木黄酮治疗宫颈癌潜力的人类研究奠定基础。
A Comprehensive Review of Genistein’s Effects in Preclinical Models of Cervical Cancer
肿瘤(癌症)患者之家