Background: International guidelines have already highlighted the beneficial effects of exercise in common cancer entities. However, specific recommendations for pancreatic cancer are still missing. This scoping review aimed to evaluate the impact of exercise training on patient-specific outcomes in pancreatic cancer patients. Methods: A literature search was undertaken using PubMed, Web of Science, and Cochrane Library. We included randomized controlled trials (RCTs) published before August 2023 with structured exercise interventions during or after pancreatic cancer treatment. Results: Seven articles that prescribed home-based or supervised exercise with aerobic or resistance training or both were reviewed. The results indicate that exercise is feasible and safe in pancreatic cancer patients. Furthermore, exercise was associated with improved quality of life, cancer-related fatigue, and muscle strength. Concerning other outcomes, heterogeneous results were reported. We identified a lack of evidence, particularly for patients with advanced pancreatic cancer. Conclusion: Exercise interventions in pancreatic cancer patients are feasible and can lead to improved quality of life, cancer-related fatigue, and muscle strength. However, further studies with larger sample sizes are needed to clarify the potential of exercise in pancreatic cancer, in particular for advanced stages.
背景：国际指南已明确指出运动对常见癌症类型的益处。然而，针对胰腺癌的具体运动建议仍属空白。本范围综述旨在评估运动训练对胰腺癌患者个体化结局指标的影响。方法：通过PubMed、Web of Science和Cochrane图书馆进行文献检索，纳入2023年8月前发表的、在胰腺癌治疗期间或治疗后实施结构化运动干预的随机对照试验。结果：共纳入七篇文献，涉及以家庭为基础或监督下的有氧训练、抗阻训练或二者结合的运动方案。结果表明运动干预对胰腺癌患者具有可行性与安全性，且与生活质量改善、癌因性疲乏缓解及肌力增强相关。其他结局指标的报告结果存在异质性。研究发现目前缺乏针对晚期胰腺癌患者的运动干预证据。结论：胰腺癌患者的运动干预具有可行性，并能改善生活质量、缓解癌因性疲乏及增强肌肉力量。但未来仍需更大样本量的研究以明确运动对胰腺癌（特别是晚期患者）的潜在效益。
肿瘤(癌症)患者之家