文章：

免疫正电子发射断层扫描靶向受体酪氨酸激酶：临床应用

ImmunoPET Targeting Receptor Tyrosine Kinase: Clinical Applications

原文发布日期：18 December 2023

DOI: 10.3390/cancers15245886

类型: Article

开放获取: 是

英文摘要：

Receptor tyrosine kinases, or RTKs, are one large family of cell surface receptors involved in signal transduction, which represent an integral part of the signaling pathways. They play a crucial role in most important cellular processes, starting with the cell cycle, proliferation and differentiation, as well as cell migration, metabolism and survival. The introduction of ImmunoPET evaluating the expression of RTKs by specific monoclonal antibodies (mAbs) or antibody fragments is regarded as a promising tool for imaging treatment efficacy and developing anticancer therapeutics. Our review focuses mainly on the current clinical research regarding ImmunoPET targeting RTKs, with particular interest in the epidermal growth factor family, or HER family, and vascular endothelial-derived growth factor/receptor.

摘要翻译： 

受体酪氨酸激酶（RTKs）是一大类参与信号转导的细胞表面受体，是信号通路的重要组成部分。它们在细胞周期、增殖与分化、细胞迁移、代谢及存活等关键细胞过程中发挥着至关重要的作用。通过特异性单克隆抗体（mAbs）或其片段评估RTKs表达的免疫正电子发射断层扫描（ImmunoPET）技术，被视为评估治疗效果和开发抗癌疗法的有前景的成像工具。本综述主要聚焦于当前针对RTKs的免疫PET临床研究，尤其关注表皮生长因子受体家族（HER家族）以及血管内皮生长因子及其受体的相关进展。

原文链接：

ImmunoPET Targeting Receptor Tyrosine Kinase: Clinical Applications