文章：

DDX5在舌癌中发挥肿瘤抑制因子功能

DDX5 Functions as a Tumor Suppressor in Tongue Cancer

原文发布日期：18 December 2023

DOI: 10.3390/cancers15245882

类型: Article

开放获取: 是

英文摘要：

DEAD-box polypeptide 5 (DDX5), a DEAD-box RNA helicase, is a multifunctional protein that plays important roles in many physiological and pathological processes. Contrary to its documented oncogenic role in a wide array of cancers, we herein demonstrate that DDX5 serves as a tumor suppressor in tongue cancer. The high expression of DDX5 is correlated with better prognosis for clinical tongue cancer patients. DDX5 downregulates the genes associated with tongue cancer progression. The knockdown of DDX5 promotes, while the overexpression of DDX5 inhibits, tongue cancer proliferation, development, and cisplatin resistance. Furthermore, the expression of DDX5 in tongue cancer is associated with immune cell infiltration in the tumor microenvironment. Specifically, the expression of DDX5 is associated with the reduced infiltration of M2 macrophages and increased infiltration of T cell clusters, which may contribute to anticancer effects in the tumor microenvironment. In this study, we establish DDX5 as a valuable prognostic biomarker and an important tumor suppressor in tongue cancer.

摘要翻译： 

DEAD-box多肽5（DDX5）作为一种DEAD-box RNA解旋酶，是一种多功能蛋白，在多种生理和病理过程中发挥重要作用。与文献中广泛报道其在多种癌症中的促癌作用相反，本研究揭示DDX5在舌癌中发挥肿瘤抑制功能。DDX5的高表达与舌癌患者更好的临床预后相关。DDX5能够下调与舌癌进展相关的基因表达。敲低DDX5促进舌癌增殖、发展及顺铂耐药性，而过表达DDX5则抑制这些恶性表型。此外，DDX5在舌癌中的表达与肿瘤微环境中的免疫细胞浸润密切相关。具体而言，DDX5表达与M2型巨噬细胞浸润减少及T细胞簇浸润增加相关，这可能在肿瘤微环境中发挥抗癌作用。本研究确立了DDX5作为舌癌重要的预后生物标志物和肿瘤抑制因子。

原文链接：

DDX5 Functions as a Tumor Suppressor in Tongue Cancer