文章：

局部晚期与寡转移性胰腺腺癌的治疗策略

Therapy of Locally Advanced and Oligometastatic Pancreatic Adenocarcinoma

原文发布日期：18 December 2023

DOI: 10.3390/cancers15245881

类型: Article

开放获取: 是

英文摘要：

Pancreatic adenocarcinoma is a lethal disease, and surgical resection remains the only curative treatment option. Unfortunately, upon primary diagnosis, only 15–20% of all patients with pancreatic ductal adenocarcinoma (PDAC) have localized disease that is eligible for operation. The remainder of patients either have borderline resectable or locally advanced disease or present with distant metastasis. In this review, we present a comprehensive overview regarding the current strategies and future directions in the multimodal therapy of locally advanced and oligometastasized pancreatic adenocarcinoma and discuss the benefit of surgery following neoadjuvant therapy in these patients.

摘要翻译： 

胰腺腺癌是一种致命性疾病，手术切除仍是目前唯一可能根治的治疗方案。遗憾的是，在初次确诊时，仅有15%-20%的胰腺导管腺癌患者处于可手术的局部病变阶段。其余患者则处于临界可切除或局部进展期，或已出现远处转移。本综述系统阐述了当前局部进展期及寡转移性胰腺腺癌多模式治疗的策略与未来发展方向，并探讨了新辅助治疗后手术干预对这类患者的临床获益。

原文链接：

Therapy of Locally Advanced and Oligometastatic Pancreatic Adenocarcinoma