Cancer therapeutics face significant challenges due to drug resistance and tumour recurrence. The tumour microenvironment (TME) is a crucial contributor and essential hallmark of cancer. It encompasses various components surrounding the tumour, including intercellular elements, immune system cells, the vascular system, stem cells, and extracellular matrices, all of which play critical roles in tumour progression, epithelial–mesenchymal transition, metastasis, drug resistance, and relapse. These components interact with multiple signalling pathways, positively or negatively influencing cell growth. Abnormal regulation of the Wnt signalling pathway has been observed in tumorigenesis and contributes to tumour growth. A comprehensive understanding and characterisation of how different cells within the TME communicate through signalling pathways is vital. This review aims to explore the intricate and dynamic interactions, expressions, and alterations of TME components and the Wnt signalling pathway, offering valuable insights into the development of therapeutic applications.
癌症治疗因耐药性和肿瘤复发面临重大挑战。肿瘤微环境作为癌症的关键促成因素和重要标志，包含肿瘤周围多种组分，如细胞间成分、免疫系统细胞、血管系统、干细胞及细胞外基质等，这些组分在肿瘤进展、上皮-间质转化、转移、耐药及复发过程中均发挥关键作用。它们通过多种信号通路相互作用，对细胞生长产生正向或负向调控。其中Wnt信号通路的异常调控已被证实参与肿瘤发生发展过程。深入理解并阐明肿瘤微环境中不同细胞如何通过信号通路进行交流至关重要。本综述旨在探讨肿瘤微环境组分与Wnt信号通路之间复杂而动态的相互作用、表达及改变，为治疗应用的开发提供重要见解。
肿瘤(癌症)患者之家