Glioblastoma (GBM) represents a paramount challenge as the most formidable primary brain tumor characterized by its rapid growth, aggressive invasiveness, and remarkable heterogeneity, collectively impeding effective therapeutic interventions. The cancer stem cells within GBM, GBM stem cells (GSCs), hold pivotal significance in fueling tumor advancement, therapeutic refractoriness, and relapse. Given their unique attributes encompassing self-renewal, multipotent differentiation potential, and intricate interplay with the tumor microenvironment, targeting GSCs emerges as a critical strategy for innovative GBM treatments. Natural killer (NK) cells, innate immune effectors recognized for their capacity to selectively detect and eliminate malignancies without the need for prior sensitization, offer substantial therapeutic potential. Harnessing the inherent capabilities of NK cells can not only directly engage tumor cells but also augment broader immune responses. Encouraging outcomes from clinical investigations underscore NK cells as a potentially effective modality for cancer therapy. Consequently, NK cell-based approaches hold promise for effectively targeting GSCs, thereby presenting an avenue to enhance treatment outcomes for GBM patients. This review outlines GBM’s intricate landscape, therapeutic challenges, GSC-related dynamics, and elucidates the potential of NK cell as an immunotherapeutic strategy directed towards GSCs.
胶质母细胞瘤（GBM）作为最具挑战性的原发性脑肿瘤，以其快速生长、侵袭性强及显著异质性为特征，这些因素共同阻碍了有效治疗干预的实施。GBM中的癌症干细胞——GBM干细胞（GSCs），在驱动肿瘤进展、治疗抵抗及复发中具有关键作用。鉴于其自我更新、多向分化潜能以及与肿瘤微环境复杂互动的独特属性，靶向GSCs已成为创新性GBM治疗的重要策略。自然杀伤（NK）细胞作为先天免疫效应细胞，以其无需预先致敏即可选择性识别并清除恶性肿瘤的能力而备受关注，展现出显著的治疗潜力。利用NK细胞的固有功能不仅能直接作用于肿瘤细胞，还能增强更广泛的免疫应答。临床研究取得的积极成果进一步证实了NK细胞作为癌症治疗潜在有效手段的价值。因此，基于NK细胞的治疗策略有望精准靶向GSCs，从而为改善GBM患者的治疗效果提供新途径。本文综述了GBM的复杂病理特征、治疗挑战、GSCs相关动态机制，并系统阐述了NK细胞作为靶向GSCs的免疫治疗策略的潜在价值。
Unlocking Glioblastoma Secrets: Natural Killer Cell Therapy against Cancer Stem Cells
肿瘤(癌症)患者之家