文章：

早期（T1–T2 N0 M0）肛周鳞状细胞癌放射治疗中淋巴结选择性照射范围的选择与界定：一项叙述性临床综述与批判性评价

Nodal Elective Volume Selection and Definition during Radiation Therapy for Early Stage (T1–T2 N0 M0) Perianal Squamous Cell Carcinoma: A Narrative Clinical Review and Critical Appraisal

原文发布日期：14 December 2023

DOI: 10.3390/cancers15245833

类型: Article

开放获取: 是

英文摘要：

Distinction between anal canal and perianal squamous cell carcinomas (pSCCs) is essential, as these two subgroups have different anatomical, histological, and lymphatic drainage features. Early-stage true perianal tumors are very uncommon and have been rarely included in clinical trials. Perianal skin cancers and aCCs are included in the same tumor classification, even though they have different lymphatic drainage features. Furthermore, pSCCs are treated similarly to carcinomas originating from the anal canal. Radiation therapy (RT) is an essential treatment for anal canal tumors. Guidelines do not differentiate between treatment volumes for perianal tumors and anal cancers. So far, in pSCC, no study has considered modulating treatment volume selection according to the stage of the disease. We conducted a narrative literature review to describe the sites at higher risk for microscopic disease in patients with early-stage perianal cancers (T1–T2 N0 M0) to propose a well-thought selection of RT elective volumes.

摘要翻译： 

区分肛管与肛周鳞状细胞癌（pSCCs）至关重要，因为这两个亚组具有不同的解剖学、组织学及淋巴引流特征。早期真性肛周肿瘤极为罕见，临床研究中鲜有纳入。尽管肛周皮肤癌与肛管癌具有不同的淋巴引流特征，它们仍被归入同一肿瘤分类。此外，肛周鳞状细胞癌的治疗方式常与源自肛管的癌相似。放射治疗（RT）是肛管肿瘤的重要治疗手段，现有指南并未区分肛周肿瘤与肛管癌的治疗靶区范围。迄今为止，在肛周鳞状细胞癌领域，尚无研究考虑根据疾病分期调整治疗靶区的选择。我们通过叙述性文献综述，描述了早期肛周癌（T1–T2 N0 M0）患者中微观病灶高风险区域，旨在提出经过深思熟虑的放射治疗选择性靶区方案。

原文链接：

Nodal Elective Volume Selection and Definition during Radiation Therapy for Early Stage (T1–T2 N0 M0) Perianal Squamous Cell Carcinoma: A Narrative Clinical Review and Critical Appraisal