Gastrointestinal cancers have become a huge problem worldwide as the number of new cases continues to increase. Due to the growing need to explore new biomarkers and therapeutic targets for the detection and treatment of cancerous lesions, we sought to elucidate the role of Pentraxin-3 in the progression of cancerous lesions, as it is involved in the process of angiogenesis and inflammation. Statistically significant changes in the concentration of this parameter have emerged in many gastrointestinal cancer patients. Moreover, it is related to the advancement of cancer, as well as processes leading to the development of those changes. In the case of studies concerning tissue material, both increased and decreased tissue expression of the tested parameter were observed and were dependent on the type of cancer. In the case of cell lines, both human and animal, a significant increase in Pentraxin 3 gene expression was observed, which confirmed the changes observed at the protein level. In conclusion, it can be assumed that PTX3, both at the level of gene expression and protein concentrations, is highly useful in the detection of gastrointestinal cancers, and its use as a biomarker and/or therapeutic target may be useful in the future.
随着新发病例数量持续攀升，胃肠道癌症已成为全球性重大健康问题。鉴于癌症病变检测与治疗领域对新生物标志物和治疗靶点的探索需求日益增长，本研究旨在阐明正五聚蛋白-3在癌症病变进展中的作用机制，因其参与血管生成和炎症过程。大量胃肠道癌症患者中该参数浓度均出现统计学显著变化，且其变化与癌症进展程度及病变发展过程密切相关。在组织材料研究中，受试参数的组织表达水平呈现升高或降低的双向变化，其变化模式取决于癌症类型。在人类及动物细胞系实验中，均观察到Pentraxin 3基因表达显著上调，这从蛋白质层面证实了前述变化。综上所述，PTX3在基因表达和蛋白浓度两个层面均对胃肠道癌症检测具有重要价值，未来或可作为生物标志物和/或治疗靶点发挥临床效用。
肿瘤(癌症)患者之家