文章：

放射基因组学：在直肠癌管理中的当代应用

Radiogenomics: Contemporary Applications in the Management of Rectal Cancer

原文发布日期：12 December 2023

DOI: 10.3390/cancers15245816

类型: Article

开放获取: 是

英文摘要：

Radiogenomics, a sub-domain of radiomics, refers to the prediction of underlying tumour biology using non-invasive imaging markers. This novel technology intends to reduce the high costs, workload and invasiveness associated with traditional genetic testing via the development of ‘imaging biomarkers’ that have the potential to serve as an alternative ‘liquid-biopsy’ in the determination of tumour biological characteristics. Radiogenomics also harnesses the potential to unlock aspects of tumour biology which are not possible to assess by conventional biopsy-based methods, such as full tumour burden, intra-/inter-lesion heterogeneity and the possibility of providing the information of tumour biology longitudinally. Several studies have shown the feasibility of developing a radiogenomic-based signature to predict treatment outcomes and tumour characteristics; however, many lack prospective, external validation. We performed a systematic review of the current literature surrounding the use of radiogenomics in rectal cancer to predict underlying tumour biology.

摘要翻译： 

放射基因组学作为放射组学的一个分支领域，指的是利用无创影像标志物预测肿瘤的潜在生物学特性。这项新兴技术旨在通过开发"影像生物标志物"，降低传统基因检测的高成本、工作量和侵入性，这些标志物有望作为替代"液体活检"的手段来确定肿瘤生物学特征。放射基因组学还能揭示传统活检方法无法评估的肿瘤生物学特性，例如整体肿瘤负荷、病灶内/病灶间异质性，并具备纵向提供肿瘤生物学信息的潜力。多项研究已证实基于放射基因组学特征预测治疗效果和肿瘤特性的可行性，但多数研究缺乏前瞻性外部验证。本文系统综述了当前关于利用放射基因组学预测直肠癌潜在生物学特性的相关文献。

原文链接：

Radiogenomics: Contemporary Applications in the Management of Rectal Cancer