文章：

超顺磁性人工细胞PLGA-Fe3O4微/纳米胶囊用于癌症靶向递送

Superparamagnetic Artificial Cells PLGA-Fe3O4Micro/Nanocapsules for Cancer Targeted Delivery

原文发布日期：12 December 2023

DOI: 10.3390/cancers15245807

类型: Article

开放获取: 是

英文摘要：

Artificial cells have been extensively used in many fields, such as nanomedicine, biotherapy, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, and the COVID-19 vaccine. The unique properties of superparamagnetic Fe3O4nanoparticles have contributed to increased interest in using superparamagnetic artificial cells (PLGA-Fe3O4micro/nanocapsules) for targeted therapy. In this review, the preparation methods of Fe3O4NPs and superparamagnetic artificial cell PLGA-drug-Fe3O4micro/nanocapsules are discussed. This review also focuses on the recent progress of superparamagnetic PLGA-drug-Fe3O4micro/nanocapsules as targeted therapeutics. We shall concentrate on the use of superparamagnetic artificial cells in the form of PLGA-drug-Fe3O4nanocapsules for magnetic hyperthermia/photothermal therapy and cancer therapies, including lung breast cancer and glioblastoma.

摘要翻译： 

人工细胞已广泛应用于纳米医学、生物治疗、血液替代品、药物递送、酶/基因治疗、癌症治疗及COVID-19疫苗等多个领域。超顺磁性四氧化三铁纳米颗粒的独特性质，促使学界对利用超顺磁性人工细胞（PLGA-Fe₃O₄微/纳米胶囊）进行靶向治疗的研究兴趣日益增长。本综述系统探讨了四氧化三铁纳米颗粒及超顺磁性人工细胞PLGA-药物-Fe₃O₄微/纳米胶囊的制备方法，重点论述了该类超顺磁性微/纳米胶囊作为靶向治疗剂的最新研究进展，并聚焦于超顺磁性人工细胞（PLGA-药物-Fe₃O₄纳米胶囊形式）在磁热疗/光热疗及肺癌、乳腺癌与胶质母细胞瘤等癌症治疗中的应用。

原文链接：

Superparamagnetic Artificial Cells PLGA-Fe3O4Micro/Nanocapsules for Cancer Targeted Delivery