Atypical and malignant cutaneous tumors are understudied in the pediatric population, with limited data on long-term follow-up. This study examines pediatric (0–18 years) atypical melanocytic proliferations over a twenty-year period (January 2002–December2022) using the EPIC SlicerDicer at our institution. Over a twenty-year period, there were 55 cases of pediatric melanoma (53 patients). The median follow-up time was 8 years, 11 months. A proportion of 96% were treated with wide local excision (WLE), and 47% had a sentinel lymph node biopsy (SLNB) (35% positive rate). There were 101 atypical Spitz tumor cases (85% atypical Spitz tumors, 15% Spitz melanoma), with a median follow-up duration of 9 years. A proportion of 77% were treated with WLE (with one patient dying of metastatic disease). There were 10 cases of atypical melanocytic proliferations not otherwise specified, including 5 pigmented epithelioid melanocytomas (PEM), 4 deep-penetrating nevi, and 1 atypical cellular blue nevus. This study adds to the growing body of knowledge on pediatric atypical cutaneous melanocytic proliferations, aligning with many described characteristics such as disease location and overall survival rates, with distinct exceptions (higher melanoma positive SLNB rate, lower atypical Spitz tumor WLE rate, and a case of fatal metastatic atypical Spitz tumor).
非典型与恶性皮肤肿瘤在儿科群体中的研究尚不充分，关于长期随访的数据有限。本研究利用本机构的EPIC SlicerDicer工具，对二十年期间（2002年1月至2022年12月）儿童（0-18岁）非典型黑素细胞增生性病变进行了分析。在二十年间，共发现55例儿童黑色素瘤（涉及53名患者），中位随访时间为8年11个月。其中96%的病例接受了广泛局部切除术治疗，47%进行了前哨淋巴结活检（阳性率为35%）。此外，共发现101例非典型斯皮茨肿瘤（85%为非典型斯皮茨肿瘤，15%为斯皮茨黑色素瘤），中位随访时长为9年，77%的病例接受了广泛局部切除术治疗（其中1例患者因转移性疾病死亡）。另有10例未特指的非典型黑素细胞增生性病变，包括5例色素性上皮样黑素细胞瘤、4例深部穿透性痣及1例非典型细胞性蓝痣。本研究丰富了关于儿童非典型皮肤黑素细胞增生性病变的认知体系，其疾病部位分布与总体生存率等特征与多数已有描述相符，但也存在明显例外（如黑色素瘤前哨淋巴结活检阳性率较高、非典型斯皮茨肿瘤广泛局部切除术实施率较低，以及出现致死性转移性非典型斯皮茨肿瘤病例）。
肿瘤(癌症)患者之家