文章：

透明细胞肾细胞癌中一氧化氮循环及相关分子通路的紊乱

Disturbances in Nitric Oxide Cycle and Related Molecular Pathways in Clear Cell Renal Cell Carcinoma

原文发布日期：11 December 2023

DOI: 10.3390/cancers15245797

类型: Article

开放获取: 是

英文摘要：

It is important to note that maintaining adequate levels of nitric oxide (NO), the turnover, and the oxidation level of nitrogen are essential for the optimal progression of cellular processes, and alterations in the NO cycle indicate a crucial step in the onset and progression of multiple diseases. Cellular accumulation of NO and reactive nitrogen species in many types of tumour cells is expressed by an increased susceptibility to oxidative stress in the tumour microenvironment. Clear cell renal cell carcinoma (ccRCC) is a progressive metabolic disease in which tumour cells can adapt to metabolic reprogramming to enhance NO production in the tumour space. Understanding the factors governing NO biosynthesis metabolites in ccRCC represents a relevant, valuable approach to studying NO-based anticancer therapy. Exploring the molecular processes mediated by NO, related disturbances in molecular pathways, and NO-mediated signalling pathways in ccRCC could have significant therapeutic implications in managing and treating this condition.

摘要翻译： 

值得注意的是，维持一氧化氮（NO）的充足水平、其周转率以及氮的氧化水平对于细胞过程的最优进展至关重要，而NO循环的改变标志着多种疾病发生和发展的关键步骤。多种肿瘤细胞中NO和活性氮物质的积累表现为肿瘤微环境对氧化应激的易感性增加。透明细胞肾细胞癌（ccRCC）是一种进展性代谢疾病，其中肿瘤细胞能够适应代谢重编程以增强肿瘤空间内的NO产生。理解ccRCC中调控NO生物合成代谢物的因素，是研究基于NO的抗癌疗法的一种相关且有价值的方法。探索ccRCC中由NO介导的分子过程、相关分子通路的紊乱以及NO介导的信号通路，可能对管理和治疗该疾病具有重要的治疗意义。

原文链接：

Disturbances in Nitric Oxide Cycle and Related Molecular Pathways in Clear Cell Renal Cell Carcinoma