文章：

胶质母细胞瘤的治疗靶向及其与微环境的相互作用

Therapeutic Targeting of Glioblastoma and the Interactions with Its Microenvironment

原文发布日期：10 December 2023

DOI: 10.3390/cancers15245790

类型: Article

开放获取: 是

英文摘要：

Glioblastoma (GBM) is the most common primary malignant brain tumour, and it confers a dismal prognosis despite intensive multimodal treatments. Whilst historically, research has focussed on the evolution of GBM tumour cells themselves, there is growing recognition of the importance of studying the tumour microenvironment (TME). Improved characterisation of the interaction between GBM cells and the TME has led to a better understanding of therapeutic resistance and the identification of potential targets to block these escape mechanisms. This review describes the network of cells within the TME and proposes treatment strategies for simultaneously targeting GBM cells, the surrounding immune cells, and the crosstalk between them.

摘要翻译： 

胶质母细胞瘤（GBM）是最常见的原发性恶性脑肿瘤，尽管采用强化的多模式治疗，其预后依然极差。传统上，研究主要聚焦于GBM肿瘤细胞自身的演变，但人们日益认识到研究肿瘤微环境（TME）的重要性。通过对GBM细胞与TME之间相互作用的深入表征，我们得以更好地理解治疗抵抗机制，并识别出阻断这些逃逸途径的潜在靶点。本综述阐述了TME内的细胞网络，并提出了同时靶向GBM细胞、周围免疫细胞及其间相互作用的治疗策略。

原文链接：

Therapeutic Targeting of Glioblastoma and the Interactions with Its Microenvironment