Multimodal prehabilitation is the process of enhancing physiological, nutritional, and psychological resilience to increase patients’ functional capacity before major cancer surgery and aims to empower the patient to withstand the pending stress of major surgery and ultimately to improve long-term outcomes. The effect of physical prehabilitation to counteract the physical decline in surgical cancer patients has been documented; however, long-term results have not yet been published. This follow-up study aims to evaluate 1-year results on the efficacy of physical prehabilitation after bladder cancer surgery. The efficacy of prehabilitation was measured over the course of 1 year in 107 patients randomized to (1) pre- and rehabilitation or (2) standard care divided byn= 50 in the intervention (I) andn= 57 in the standard group (S). Physical function was measured by muscle leg power, and nutritional status was expressed with handgrip strength. Prehabilitation in major bladder cancer surgery can significantly improve physical function with 19.8 Watt/kg (p= 0.04), lean body mass (p= 0.047) and body cell mass (p= 0.03), and regained nutritional status one year after surgery. The results demonstrate that the restoration of physical function is vital to a full recovery.
多模式预康复是通过增强生理、营养及心理韧性，在重大癌症手术前提升患者功能储备的过程，旨在使患者能够承受重大手术带来的应激压力，最终改善长期预后。已有研究证实物理预康复可有效缓解外科癌症患者的体能衰退，但其长期效果尚未见报道。本随访研究旨在评估膀胱癌术后物理预康复的1年疗效。研究对107例患者进行为期1年的随机分组评估：干预组（I组）50例接受预康复及康复联合方案，标准组（S组）57例接受常规护理。通过腿部肌肉功率评估身体功能，握力测试反映营养状态。结果显示，重大膀胱癌手术患者接受预康复后1年，其身体功能显著提升19.8瓦/千克（p=0.04），去脂体重（p=0.047）与体细胞质量（p=0.03）明显改善，营养状态得到恢复。研究证实，身体功能的恢复是实现全面康复的关键要素。
One-Year Follow-Up after Multimodal Prehabilitation Interventions in Radical Cystectomy
肿瘤(癌症)患者之家