Background: Baseline quality of life (bQL) has been shown to be a predictor of the clinical outcome of oncological patients. The primary objective of the present study was to examine the role of bQL as a treatment predictor in oncological patients. Methods: In this prospective study, all-stage cancer patients registered in the Network Oncology registry were enrolled, and their bQL at diagnosis was evaluated. Results: Five hundred and thirty-eight oncological patients were eligible (median age 64 years). We show that survival-predicting bQL variables such as pain, low physical functioning or financial burden at tumor diagnosis were linked to lower systemic treatment (p= 0.03), reduced surgery (p= 0.007) or reduced oncological treatment compliance (0.01), respectively. Lastly, female gender and older cancer patients exhibited a tempered bQL. Conclusion: Our study is one of the first to reveal that bQL at tumor diagnosis is significantly associated with the prediction of oncological treatment with distinctive age- and gender-related patterns. Our results emphasize the need to address the physical, psychosocial, and financial burden of cancer patients prior to their oncological treatment with respect to age and gender. The associations found here pave the way for early integration of patient-reported outcomes into oncological supportive concepts.
背景：基线生活质量已被证实是预测肿瘤患者临床结局的重要因素。本研究旨在探讨基线生活质量对肿瘤患者治疗决策的预测作用。方法：本前瞻性研究纳入肿瘤网络登记系统中所有分期的癌症患者，评估其确诊时的基线生活质量。结果：共538例肿瘤患者符合入组标准（中位年龄64岁）。研究发现，在肿瘤确诊时具有生存预测价值的基线生活质量指标（如疼痛、低体能状态或经济负担）分别与全身治疗减少（p=0.03）、手术率降低（p=0.007）及治疗依从性下降（p=0.01）显著相关。此外，女性及高龄患者表现出更为缓和的基线生活质量特征。结论：本研究首次揭示肿瘤确诊时的基线生活质量与治疗决策预测存在显著关联，且呈现年龄与性别特异性模式。研究结果强调，在制定肿瘤治疗方案时需特别关注不同年龄与性别患者在生理、心理及经济层面的多维负担。本研究发现的关联性为早期将患者报告结局整合至肿瘤支持治疗体系提供了理论依据。
Self-Reported Baseline Quality of Life Mirrors Treatment-Specific Characteristics of Cancer Patients
肿瘤(癌症)患者之家