Soft tissue sarcomas (STSs) are a rare heterogeneous group of malignant neoplasms characterized by their aggressive course and poor response to treatment. This determines the relevance of research aimed at studying the pathogenesis of STSs. By now, it is known that STSs is characterized by complex relationships between the tumor cells and immune cells of the microenvironment. Dynamic interactions between tumor cells and components of the microenvironment enhance adaptation to changing environmental conditions, which provides the high aggressive potential of STSs and resistance to antitumor therapy. Today, active research is being conducted to find effective antitumor drugs and to evaluate the possibility of using therapy with immune cells of STS. The difficulty in assessing the efficacy of new antitumor options is primarily due to the high heterogeneity of this group of malignant neoplasms. Studying the role of immune cells in the microenvironment in the progression STSs and resistance to antitumor therapies will provide the discovery of new biomarkers of the disease and the prediction of response to immunotherapy. In addition, it will help to initially divide patients into subgroups of good and poor response to immunotherapy, thus avoiding wasting precious time in selecting the appropriate antitumor agent.
软组织肉瘤（STSs）是一类罕见且异质性的恶性肿瘤，其特点是病程侵袭性强且对治疗反应不佳。这决定了研究STSs发病机制的重要性。目前已知，STSs的特征在于肿瘤细胞与微环境免疫细胞之间存在复杂的相互作用。肿瘤细胞与微环境成分之间的动态交互增强了其对环境变化的适应能力，从而赋予STSs高度侵袭潜能及对抗肿瘤治疗的耐药性。当前，针对寻找有效的抗肿瘤药物及评估利用免疫细胞治疗STSs可能性的研究正在积极开展。评估新型抗肿瘤方案疗效的主要困难在于这类恶性肿瘤的高度异质性。研究微环境中免疫细胞在STSs进展及抗肿瘤治疗耐药中的作用，将有助于发现新的疾病生物标志物并预测免疫治疗反应。此外，这将有助于在初始阶段将患者划分为对免疫治疗反应良好和不良的亚组，从而避免在选择合适抗肿瘤药物时浪费宝贵时间。
Immune Cells in the Tumor Microenvironment of Soft Tissue Sarcomas
肿瘤(癌症)患者之家