文章：

过氧化物酶体孔蛋白与抗氧化转录因子在乳腺癌治疗抵抗中的作用

The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance

原文发布日期：8 December 2023

DOI: 10.3390/cancers15245747

类型: Article

开放获取: 是

英文摘要：

Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multiple processes and many signaling pathways that support each other, making it difficult to overcome once established. Here, we discuss cellular-oxidative-stress-modulating factors focusing on transcription factors NRF2, FOXO family, and peroxiporins, as well as their possible contribution to MDR. This is significant because oxidative stress is a consequence of radiotherapy, chemotherapy, and immunotherapy, and the activation of detoxification pathways could modulate the cellular response to therapy and could support MDR. These proteins are not directly responsible for MDR, but they support the survival of cancer cells under stress conditions.

摘要翻译： 

乳腺癌仍是各年龄段女性死亡的主要原因，其根本在于治疗抵抗性导致疾病进展及转移灶形成。多药耐药（MDR）作为一种多因素作用过程，是造成治疗失败的关键机制。MDR涉及多个相互协同的生物学进程与信号通路，一旦形成便难以逆转。本文聚焦转录因子NRF2、FOXO家族及过氧化物通道蛋白等细胞氧化应激调控因子，探讨其在MDR形成中的潜在作用。该研究具有重要意义，因为放疗、化疗及免疫治疗均会引发氧化应激，而解毒通路的激活可能调节细胞对治疗的反应并促进MDR发展。这些蛋白虽非直接导致MDR，但能增强癌细胞在应激状态下的生存能力。

原文链接：

The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance