Objective: To analyze the factors associated with overall survival (OS) and progression-free survival (PFS) in patients with ovarian cancer in Cyprus. Methods: We retrospectively analyzed data from patients with histologically confirmed epithelial ovarian cancer (EOC) and primary peritoneal cancer (PPC). Results: A total of 106 women diagnosed with ovarian cancer were included, with a median age at diagnosis of 58 years. The Kaplan–Meier survival analysis showed a median OS of 41 months (95% C.I = 36.9, 45.1), and the FIGO stage (p< 0.001), type of surgery (p< 0.001) and performance status (p< 0.001) were identified as statistically significant prognostic factors for OS. PFS analysis revealed the FIGO stage (p= 0.006) and the performance status (p< 0.001) as significant prognostic factors. Additionally, a Cox regression analysis for median OS was performed for patients with high-grade serous carcinoma, identifying the performance status, FIGO stage, and type of surgery as prognostic factors in univariate analysis. However, in the subsequent multivariate analysis, the performance status and the FIGO stage were confirmed to be the only statistically significant prognostic factors for OS (p< 0.05). Conclusions: This study confirms that the FIGO stage, performance status, and surgery type were considered as prognostic factors for OS in ovarian cancer.
目的：分析塞浦路斯卵巢癌患者总生存期（OS）和无进展生存期（PFS）的相关因素。方法：我们回顾性分析了经组织学确诊的上皮性卵巢癌（EOC）和原发性腹膜癌（PPC）患者的数据。结果：共纳入106例确诊卵巢癌的女性患者，诊断时中位年龄为58岁。Kaplan-Meier生存分析显示中位OS为41个月（95% CI = 36.9, 45.1），其中FIGO分期（p<0.001）、手术类型（p<0.001）和体能状态（p<0.001）被确定为OS的统计学显著预后因素。PFS分析显示FIGO分期（p=0.006）和体能状态（p<0.001）是显著预后因素。此外，针对高级别浆液性癌患者进行了中位OS的Cox回归分析，单变量分析显示体能状态、FIGO分期和手术类型均为预后因素。然而，在随后的多变量分析中，仅体能状态和FIGO分期被确认为OS的统计学显著预后因素（p<0.05）。结论：本研究证实FIGO分期、体能状态和手术类型是卵巢癌OS的预后因素。
Prognostic Factors Influencing Survival in Ovarian Cancer Patients: A 10-Year Retrospective Study
肿瘤(癌症)患者之家