Recent studies have shed light on alterations to the proinflammatory tumor microenvironment as a significant carcinogenic mechanism. Despite previous studies on associations between proinflammatory cytokines and lung cancer risk, few studies have been conducted in Asian populations. This study aimed to investigate associations between proinflammatory cytokines and lung cancer risk, considering histological types, in the Korean general population. We carried out a case-cohort study on the Korean National Cancer Center Community (KNCCC) cohort (lung cancer cases: 136, subcohort: 822). Pre-diagnostic serum levels of proinflammatory cytokines (i.e., IL-6, TNF-α, IL-1β, IFN-γ, and IL-10) were measured using Quantikine®ELISA. A Cox proportional-hazards regression analysis was conducted. In this study, serum levels of IL-6, IL-1β, and IFN-γ were associated with lung cancer risk. IL-6 was associated with lung cancer, regardless of the histological type. IL-1β had an association only with adenocarcinoma, while IFN-γ had an association only with squamous-cell carcinoma. This study shows associations between serum levels of IL-6, IL-1β, and IFN-γ and lung cancer risk, underscoring the potential of these cytokines to act as risk biomarkers. The utilization of these biomarkers for risk prediction may hold the promise of facilitating the identification of the high-risk population.
近期研究揭示了促炎性肿瘤微环境的改变是一种重要的致癌机制。尽管先前已有关于促炎细胞因子与肺癌风险关联的研究，但在亚洲人群中开展的研究为数不多。本研究旨在韩国普通人群中，结合组织学类型探讨促炎细胞因子与肺癌风险之间的关联。我们在韩国国立癌症中心社区队列中开展了一项病例队列研究（肺癌病例136例，亚队列822例）。使用Quantikine®酶联免疫吸附法检测了诊断前血清中促炎细胞因子（即IL-6、TNF-α、IL-1β、IFN-γ和IL-10）的水平，并进行了Cox比例风险回归分析。本研究发现，血清IL-6、IL-1β和IFN-γ水平与肺癌风险相关。IL-6与肺癌的关联不受组织学类型影响；IL-1β仅与腺癌相关，而IFN-γ仅与鳞状细胞癌相关。本研究证实了血清IL-6、IL-1β和IFN-γ水平与肺癌风险之间的关联，强调了这些细胞因子作为风险生物标志物的潜力。利用这些生物标志物进行风险预测，有望促进高危人群的识别。
肿瘤(癌症)患者之家