文章：

脑肿瘤切除腔同步磁纳米粒子热疗与高剂量率近距离放射治疗球囊植入物的评估

Evaluation of a Balloon Implant for Simultaneous Magnetic Nanoparticle Hyperthermia and High-Dose-Rate Brachytherapy of Brain Tumor Resection Cavities

原文发布日期：1 December 2023

DOI: 10.3390/cancers15235683

类型: Article

开放获取: 是

英文摘要：

Previous work has reported the design of a novel thermobrachytherapy (TBT) balloon implant to deliver magnetic nanoparticle (MNP) hyperthermia and high-dose-rate (HDR) brachytherapysimultaneouslyafter brain tumor resection, therebymaximizingtheir synergistic effect. This paper presents an evaluation of the robustness of the balloon device, compatibility of its heat and radiation delivery components, as well as thermal and radiation dosimetry of the TBT balloon. TBT balloon devices with 1 and 3 cm diameter were evaluated when placed in an external magnetic field with a maximal strength of 8.1 kA/m at 133 kHz. The MNP solution (nanofluid) in the balloon absorbs energy, thereby generating heat, while an HDR source travels to the center of the balloon via a catheter to deliver the radiation dose. A 3D-printed human skull model was filled with brain-tissue-equivalent gel for in-phantom heating and radiation measurements around four 3 cm balloons. For thein vivoexperiments, a 1 cm diameter balloon was surgically implanted in the brains of three living pigs (40–50 kg). The durability and robustness of TBT balloon implants, as well as the compatibility of their heat and radiation delivery components, were demonstrated in laboratory studies. The presence of the nanofluid, magnetic field, and heating up to 77 °C did not affect the radiation dose significantly. Thermal mapping and 2D infrared images demonstrated spherically symmetric heating in phantom as well as in brain tissue.In vivopig experiments showed the ability to heat well-perfused brain tissue to hyperthermic levels (≥40 °C) at a 5 mm distance from the 60 °C balloon surface.

摘要翻译： 

先前的研究报道了一种新型热球囊近距离放射治疗（TBT）植入装置的设计，该装置可在脑肿瘤切除术后同步实施磁性纳米颗粒（MNP）热疗与高剂量率（HDR）近距离放射治疗，从而最大化二者的协同效应。本文评估了该球囊装置的稳定性、其热疗与放射治疗组件的兼容性，以及TBT球囊的热剂量与辐射剂量学特性。研究对直径1厘米和3厘米的TBT球囊装置进行了测试，将其置于最大场强为8.1 kA/m、频率133 kHz的外部磁场中。球囊内的MNP溶液（纳米流体）吸收能量产生热量，同时HDR放射源通过导管抵达球囊中心实施辐射剂量照射。实验采用3D打印的人类颅骨模型，内部填充脑组织等效凝胶，围绕四个3厘米直径球囊进行体模内的热场与辐射测量。在活体实验中，通过手术将直径1厘米的球囊植入三头活猪（体重40-50公斤）的脑组织中。实验室研究证实了TBT球囊植入装置的耐久性与稳定性，以及其热疗与放射治疗组件的兼容性。纳米流体的存在、磁场作用以及最高77°C的加热温度均未对辐射剂量产生显著影响。热分布图与二维红外图像显示，在体模及脑组织中均呈现球对称的热场分布。活体猪实验表明，在距离球囊表面（温度60°C）5毫米处，可对血流灌注良好的脑组织加热至热疗水平（≥40°C）。

原文链接：

Evaluation of a Balloon Implant for Simultaneous Magnetic Nanoparticle Hyperthermia and High-Dose-Rate Brachytherapy of Brain Tumor Resection Cavities