文章：

护士健康研究2中轮班夜班工作、睡眠与甲状腺癌风险的关系

Rotating Night Shift Work, Sleep, and Thyroid Cancer Risk in the Nurses’ Health Study 2

原文发布日期：30 November 2023

DOI: 10.3390/cancers15235673

类型: Article

开放获取: 是

英文摘要：

Night shift work has been associated with breast, prostate, and colorectal cancer, but evidence on other types of cancer is limited. We prospectively evaluated the association of rotating night shift work, sleep duration, and sleep difficulty with thyroid cancer risk in the Nurses’ Health Study 2 (NHS2). We assessed rotating night shift work duration (years) at baseline and throughout follow-up (1989–2015) and sleep characteristics in 2001. Cox proportional hazard models, adjusted for potential confounders, were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for (a) shift work duration, (b) sleep duration, and (c) difficulty falling or staying asleep. We stratified the analyses of night shift work by sleep duration and sleep difficulty. Over 26 years of follow-up, 588 incident cases were identified among 114,534 women in the NHS2 cohort. We observed no association between night shift work and the risk of thyroid cancer. Difficulty falling or staying asleep was suggestively associated with a higher incidence of thyroid cancer when reported sometimes (HR 1.26, 95% CI 0.95, 1.66) and all or most of the time (HR 1.35, 95% CI 1.00, 1.81). Night shift workers (10+ years) with sleep difficulty all or most of the time (HR 1.47; 0.58–3.73) or with >7 h of sleep duration (HR 2.17; 95% CI, 1.21–3.92) had a higher risk of thyroid cancer. We found modest evidence for an increased risk of thyroid cancer in relation to sleep difficulty, which was more pronounced among night shift workers.

摘要翻译： 

夜班工作已被证实与乳腺癌、前列腺癌及结直肠癌相关，但与其他类型癌症关联的证据尚不充分。本研究基于护士健康研究2（NHS2）队列，前瞻性评估了轮班夜班工作、睡眠时长及睡眠障碍与甲状腺癌风险的关联。我们分别在基线期（1989年）及随访全程（至2015年）评估了轮班夜班工作时长（年数），并于2001年评估了睡眠特征。通过校正潜在混杂因素的Cox比例风险模型，计算了（a）夜班工作时长、（b）睡眠时长及（c）入睡或维持睡眠困难的风险比（HR）及其95%置信区间（CI）。研究进一步按睡眠时长与睡眠障碍对夜班工作进行了分层分析。 在NHS2队列114,534名女性长达26年的随访中，共发现588例甲状腺癌新发病例。分析显示夜班工作与甲状腺癌风险无显著关联。偶尔报告入睡或维持睡眠困难（HR 1.26，95% CI 0.95-1.66）以及持续或频繁报告此类问题（HR 1.35，95% CI 1.00-1.81）均提示可能与甲状腺癌发病率升高相关。在长期夜班工作者（≥10年）中，持续或频繁出现睡眠障碍者（HR 1.47；95% CI 0.58-3.73）及睡眠时长超过7小时者（HR 2.17；95% CI 1.21-3.92）表现出更高的甲状腺癌风险。 本研究初步发现睡眠障碍可能与甲状腺癌风险增加存在适度关联，且这种关联在夜班工作者群体中更为显著。

原文链接：

Rotating Night Shift Work, Sleep, and Thyroid Cancer Risk in the Nurses’ Health Study 2