A total of 457 patients, including 241 HR+/HER2− patients, 134 HER2+ patients, and 82 TN patients, were studied. The percentage of TILs in the stroma adjacent to the tumor cells was assessed using a 10% cutoff. The low TIL percentages were 82% in the HR+ patients, 63% in the HER2+ patients, and 56% in the TN patients (p< 0.001). MRI features such as morphology as mass or non-mass enhancement (NME), shape, margin, internal enhancement, presence of peritumoral edema, and the DCE kinetic pattern were assessed. Tumor sizes were smaller in the HR+/HER2− group (p< 0.001); HER2+ was more likely to present as NME (p= 0.031); homogeneous enhancement was mostly seen in HR+ (p< 0.001); and the peritumoral edema was present in 45% HR+, 71% HER2+, and 80% TN (p< 0.001). In each subtype, the MR features between the high- vs. low-TIL groups were compared. In HR+/HER2−, peritumoral edema was more likely to be present in those with high TILs (70%) than in those with low TILs (40%,p< 0.001). In TN, those with high TILs were more likely to present a regular shape (33%) than those with low TILs (13%,p= 0.029) and more likely to present the circumscribed margin (19%) than those with low TILs (2%,p= 0.009).
本研究共纳入457例患者，其中HR+/HER2−型241例、HER2+型134例、三阴性（TN）82例。采用10%作为临界值评估肿瘤细胞邻近间质中肿瘤浸润淋巴细胞（TILs）的比例。低TIL比例在HR+患者中为82%，HER2+患者中为63%，TN患者中为56%（p<0.001）。同时评估了MRI特征，包括形态学（肿块型或非肿块强化）、形状、边缘、内部强化特征、瘤周水肿存在情况以及动态增强曲线类型。HR+/HER2−组肿瘤体积更小（p<0.001）；HER2+型更易表现为非肿块强化（p=0.031）；均匀强化主要见于HR+型（p<0.001）；瘤周水肿在HR+型中占45%，HER2+型中占71%，TN型中占80%（p<0.001）。在各亚型中比较了高TIL组与低TIL组的MRI特征差异：在HR+/HER2−型中，高TIL组出现瘤周水肿的比例（70%）显著高于低TIL组（40%，p<0.001）；在TN型中，高TIL组呈现规则形状的比例（33%）显著高于低TIL组（13%，p=0.029），且边界清晰的比例（19%）显著高于低TIL组（2%，p=0.009）。
肿瘤(癌症)患者之家