Peritoneal metastasis (PM) is a common mode of distant metastasis in colorectal cancer (CRC) and has a poorer prognosis compared to other metastatic sites. The formation of PM foci depends on the synergistic effect of multiple molecules and the modulation of various components of the tumor microenvironment. The current treatment of CRC-PM is based on systemic chemotherapy. However, recent developments in local therapeutic modalities, such as cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC), have improved the survival of these patients. This article reviews the research progress on the mechanism, characteristics, diagnosis, and treatment strategies of CRC-PM, and discusses the current challenges, so as to deepen the understanding of CRC-PM among clinicians.
腹膜转移是结直肠癌常见的远处转移方式，与其他转移部位相比预后更差。腹膜转移灶的形成依赖于多种分子的协同作用及肿瘤微环境各成分的调节。目前结直肠癌腹膜转移的治疗以全身化疗为基础，但近年来局部治疗模式如肿瘤细胞减灭术和腹腔内化疗的发展改善了这类患者的生存。本文综述了结直肠癌腹膜转移的机制、特征、诊断及治疗策略的研究进展，并探讨当前面临的挑战，以加深临床医生对结直肠癌腹膜转移的认识。
Peritoneal Metastasis: A Dilemma and Challenge in the Treatment of Metastatic Colorectal Cancer
肿瘤(癌症)患者之家