The role of pelvic lymphadenectomy in endometrial cancer remains unclear. In this study, we aimed to investigate the influence of lymphadenectomy on progression-free and overall survival among patients diagnosed with endometrial carcinoma. This retrospective single-center study included 1532 patients operated on in a Polish reference center for gynecologic oncology at Holy Cross Hospital, Kielce, between 2002 and 2020. A total of 1004 patients underwent systematic lymphadenectomy as a part of their surgical procedure. The median number of collected lymph nodes was seven. In total, 11.6% of patients were found to have lymph node invasion. The number of lymph nodes removed correlated with patient survival. In patients in whom the number of removed lymph nodes was above the median (>7), the risk of death was reduced (HR 0.68,p= 0.002). The risk of death correlated with the presence of lymph node metastasis (HR 4.12,p< 0.001). The risk of cancer progression was associated with the number of lymph nodes removed (HR 0.54,p= 0.006), and the risk of EC recurrence was greater in patients with lymph node metastasis (HR 1.94,p= 0.016). Our study provides additional evidence that systematic lymphadenectomy may influence the disease-free and overall survival of patients with endometrial cancer. The number of lymph nodes removed correlated with patient prognosis. Further studies are needed to evaluate the use of lymphadenectomy in endometrial cancer treatment.
盆腔淋巴结清扫术在子宫内膜癌治疗中的作用尚不明确。本研究旨在探讨淋巴结清扫术对子宫内膜癌患者无进展生存期和总生存期的影响。这项回顾性单中心研究纳入了2002年至2020年间在波兰凯尔采圣十字医院妇科肿瘤诊疗中心接受手术的1532例患者。其中1004例患者在手术中接受了系统性淋巴结清扫术，淋巴结清扫中位数为7枚。总体而言，11.6%的患者存在淋巴结转移。淋巴结清扫数量与患者生存率相关：当清扫淋巴结数量高于中位数（>7枚）时，患者死亡风险降低（HR 0.68，p=0.002）。死亡风险与淋巴结转移状态显著相关（HR 4.12，p<0.001）。癌症进展风险与淋巴结清扫数量存在关联（HR 0.54，p=0.006），且淋巴结转移患者的子宫内膜癌复发风险更高（HR 1.94，p=0.016）。本研究进一步证实系统性淋巴结清扫术可能影响子宫内膜癌患者的无病生存期和总生存期，淋巴结清扫数量与患者预后相关。未来仍需进一步研究以评估淋巴结清扫术在子宫内膜癌治疗中的应用价值。
肿瘤(癌症)患者之家