Endometriosis is known to be associated with an increased risk of endometrioid and clear cell ovarian cancer. However, the association between endometriosis and endometrial cancer is controversial. Therefore, we retrospectively analyzed the medical records of women with endometrial cancer who had undergone surgery at our institution to evaluate the clinicopathological relationship between endometrial cancer and endometriosis. The study included 720 women pathologically diagnosed with endometrial cancer at our hospital between 2000 and 2020. The participants were allocated to two groups of patients with endometrial cancer: patients with endometriosis (n= 101) and patients without endometriosis (n= 619). Endometrial cancer patients with endometriosis were significantly younger (median age 54.0 vs. 58.0;p= 0.002). In addition, endometrial cancer patients with endometriosis had fewer pregnancies and deliveries (median pregnancy 1.58 vs. 1.99;p= 0.019, median delivery 1.25 vs. 1.56;p= 0.012). The percentage of patients classified as stage IA was significantly higher in those with endometrial cancer with endometriosis (68.3% vs. 56.4%;p= 0.029). In the analysis of synchronous ovarian cancer, the percentage of dual primary cancer was higher in patients with endometriosis (14.9% vs. 1.6%;p< 0.001). The association of young-onset early-stage endometrial cancer with endometriosis is an important finding that cannot be ignored clinically.
已知子宫内膜异位症与子宫内膜样癌和透明细胞卵巢癌的风险增加相关，但其与子宫内膜癌的关联性尚存争议。为此，我们回顾性分析了在本机构接受手术的子宫内膜癌患者的医疗记录，以评估子宫内膜癌与子宫内膜异位症之间的临床病理学关系。本研究纳入了2000年至2020年间在我院经病理确诊的720例子宫内膜癌患者，将其分为两组：合并子宫内膜异位症的子宫内膜癌患者（101例）与未合并子宫内膜异位症的子宫内膜癌患者（619例）。合并子宫内膜异位症的子宫内膜癌患者年龄显著更轻（中位年龄54.0岁 vs. 58.0岁；p=0.002），且妊娠及分娩次数更少（中位妊娠次数1.58次 vs. 1.99次；p=0.019，中位分娩次数1.25次 vs. 1.56次；p=0.012）。在合并子宫内膜异位症的子宫内膜癌患者中，IA期患者比例显著更高（68.3% vs. 56.4%；p=0.029）。在同时性卵巢癌的分析中，合并子宫内膜异位症患者的双原发癌比例更高（14.9% vs. 1.6%；p<0.001）。年轻发病的早期子宫内膜癌与子宫内膜异位症的关联性是一项临床上不容忽视的重要发现。
Endometrial Cancer with and without Endometriosis: Clinicopathological Differences
肿瘤(癌症)患者之家