Histopathologically, uveal melanomas (UMs) can be classified as spindle cell, mixed cell and epithelioid cell type, with the latter having a more severe prognosis. The aim of our study was to assess the correlation between the apparent diffusion coefficient (ADC) and the histologic type of UMs in order to verify the role of diffusion-weighted magnetic resonance imaging (DWI) as a noninvasive prognostic marker. A total of 26 patients with UMs who had undergone MRI and subsequent primary enucleation were retrospectively selected. The ADC of the tumor was compared with the histologic type. The data were compared using both one-way analysis of variance (ANOVA) (assessing the three histologic types separately) and the independentt-test (dichotomizing histologic subtypes as epithelioid versus non-epithelioid). Histologic type was present as follows: the epithelioid cell wasn= 4, and the spindle cell wasn= 11, the mixed cell type wasn= 11. The mean ADC was 1.06 ± 0.24 × 10−3mm2/s in the epithelioid cells, 0.98 ± 0.19 × 10−3mm2/s in the spindle cells and 0.96 ± 0.26 × 10−3mm2/s in the mixed cell type. No significant difference in the mean ADC value of the histopathologic subtypes was found, either when assessing the three histologic types separately (p= 0.76) or after dichotomizing the histologic subtypes as epithelioid and non-epithelioid (p= 0.82). DWI-ADC is not accurate enough to distinguish histologic types of UMs.
组织病理学上，葡萄膜黑色素瘤可分为梭形细胞型、混合细胞型和上皮样细胞型，其中后者预后较差。本研究旨在评估表观扩散系数与葡萄膜黑色素瘤组织学类型之间的相关性，以验证弥散加权磁共振成像作为无创预后标志物的作用。回顾性选取26例接受磁共振成像检查后行一期眼球摘除术的葡萄膜黑色素瘤患者。将肿瘤的表观扩散系数与组织学类型进行比较。数据分析采用单因素方差分析（分别评估三种组织学类型）和独立样本t检验（将组织学亚型分为上皮样与非上皮样两类）。组织学类型分布如下：上皮样细胞型4例，梭形细胞型11例，混合细胞型11例。上皮样细胞型平均表观扩散系数为（1.06±0.24）×10⁻³mm²/s，梭形细胞型为（0.98±0.19）×10⁻³mm²/s，混合细胞型为（0.96±0.26）×10⁻³mm²/s。无论是单独评估三种组织学类型（p=0.76），还是将组织学亚型分为上皮样与非上皮样两类后（p=0.82），均未发现不同组织病理学亚型间的平均表观扩散系数存在显著差异。弥散加权成像-表观扩散系数尚不足以准确区分葡萄膜黑色素瘤的组织学类型。
肿瘤(癌症)患者之家