文章：

质子泵抑制剂与韩国人群结直肠癌风险：基于国民健康保险数据的巢式病例对照研究启示

Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data

原文发布日期：27 November 2023

DOI: 10.3390/cancers15235606

类型: Article

开放获取: 是

英文摘要：

The potential connection between proton pump inhibitors (PPIs) and colorectal cancer (CRC) risk remains unclear, with specific ethnic genetic backgrounds playing a role in PPI-induced adverse effects. In this nested case–control study, we investigated the risk of CRC in relation to preceding PPI use and the duration of use using data from the Korean National Health Insurance Service–National Sample Cohort database, including 9374 incident CRC patients and 37,496 controls. To assess the impact of preceding PPI exposure (past vs. current) and use duration (days: <30, 30–90, and ≥90) on incident CRC, we conducted propensity score overlap-weighted multivariate logistic regression analyses, adjusted for confounding factors. Our findings revealed that past and current PPI users had an increased likelihood of developing CRC. Regardless of duration, individuals who used PPIs also had higher odds of developing CRC. Subgroup analyses revealed that CRC occurrence increased independent of history or duration of prior PPI use, consistent across various factors such as age, sex, income level, and residential area. These findings suggest that PPI use, regardless of past or present use and duration of use, may be related to an increased risk of developing CRC in the Korean population.

摘要翻译： 

质子泵抑制剂（PPIs）与结直肠癌（CRC）风险之间的潜在关联尚不明确，且特定种族的遗传背景在PPIs引发的不良反应中可能发挥作用。本研究采用韩国国民健康保险服务-国家样本队列数据库的数据，开展了一项巢式病例对照研究，共纳入9374例新发CRC患者及37496例对照者，旨在探讨既往使用PPIs及其使用时长与CRC风险的关系。为评估既往PPIs暴露情况（既往使用与当前使用）及使用时长（天数：<30天、30-90天、≥90天）对新发CRC的影响，我们进行了倾向评分重叠加权多变量逻辑回归分析，并对混杂因素进行了校正。研究结果显示，既往及当前使用PPIs者发生CRC的可能性均有所增加。无论使用时长如何，使用PPIs的个体发生CRC的几率也更高。亚组分析表明，无论既往PPIs使用史或使用时长如何，CRC发生率均呈上升趋势，且这一趋势在不同年龄、性别、收入水平和居住地区等因素中保持一致。这些发现提示，在韩国人群中，无论既往或当前使用PPIs，也无论使用时长如何，PPIs的使用均可能与CRC风险增加相关。

原文链接：

Proton Pump Inhibitors and Likelihood of Colorectal Cancer in the Korean Population: Insights from a Nested Case–Control Study Using National Health Insurance Data