Considering the global importance of both gout and colorectal cancer (CRC) as significant health issues with mutual relevance, we aimed to examine the risk of colorectal cancer in Korean patients with gout. In this nested case-control study, we used data from 9920 CRC patients and 39,680 controls the Korean National Health Insurance Service-National Sample Cohort database. Propensity score overlap-weighted multivariate logistic regression analyses, adjusted for confounders, were used to assess the odds ratio (OR) and 95% confidence interval (CI) of the association between gout and CRC. Adjusted OR for CRC were similar between patients with gout and the control group (0.95; 95% CI, 0.86–1.04;p= 0.282). However, after adjustment, subgroup analysis revealed an 18% reduction in the probability of CRC among patients younger than 65 years with gout (95% CI, 0.70–0.95;p= 0.009). Conversely, absence of an association between gout and subsequent CRC persisted regardless of sex, income, residence, and Charlson Comorbidity Index score, even among individuals aged 65 years or older. These results imply that gout may not be a significant independent risk factor for CRC among the general population. However, in patients younger than 65 years with gout, a slightly reduced likelihood of CRC was observed. Further research is necessary to establish a causal relationship between gout and CRC and to generalize these findings to other populations.
鉴于痛风与结直肠癌（CRC）作为具有相互关联性的重大健康问题在全球范围内的重要性，本研究旨在探讨韩国痛风患者罹患结直肠癌的风险。本项巢式病例对照研究基于韩国国民健康保险服务-国家样本队列数据库，共纳入9920例结直肠癌患者及39,680例对照人群。采用经混杂因素校正的倾向评分重叠加权多元逻辑回归分析，评估痛风与结直肠癌关联的比值比（OR）及95%置信区间（CI）。经校正后，痛风患者与对照组的结直肠癌风险比值比基本持平（0.95；95% CI 0.86-1.04；p=0.282）。然而亚组分析显示，在65岁以下痛风患者中，经校正后结直肠癌发生概率降低18%（95% CI 0.70-0.95；p=0.009）。相反，无论性别、收入、居住地及查尔森合并症指数评分如何，痛风与后续结直肠癌发病均未呈现显著关联，在65岁及以上人群中亦保持此趋势。这些结果表明，在普通人群中痛风可能并非结直肠癌的重要独立危险因素。但在65岁以下痛风患者中观察到结直肠癌发生概率略有降低。未来需进一步研究以明确痛风与结直肠癌之间的因果关系，并将这些发现推广至其他人群。
肿瘤(癌症)患者之家