Cancer remains a major health problem and is associated with cachexia in up to 80% of cases, leading to decreased survival and quality of life. Cachexia involves complex metabolic disturbances in both protein and energy balance, muscle wasting phenomena, weight loss, systemic inflammation, overall decreased performance status, and tolerability to treatment. The clinical impact of cancer cachexia is very complex, with early detection of cachectic patients and identification of predictive biomarkers being two key factors for improving survival. Thus, a better understanding of the complexity of cancer cachexia phenomena and its main pathophysiological mechanism is much needed. Our review highlights the most important information about cancer cachexia, aiming to disseminate updated research findings about this highly deadly condition.
癌症仍是主要的健康问题，高达80%的病例伴随恶病质发生，导致患者生存期与生活质量显著下降。恶病质涉及蛋白质与能量平衡的复杂代谢紊乱、肌肉萎缩现象、体重减轻、全身性炎症反应、整体功能状态下降及治疗耐受性降低。癌症恶病质的临床影响极为复杂，早期识别恶病质患者及发现预测性生物标志物是改善生存的两个关键因素。因此，亟需深入理解癌症恶病质现象的复杂性及其主要病理生理机制。本综述聚焦癌症恶病质的核心信息，旨在传播这一高致死性病症的最新研究进展。
肿瘤(癌症)患者之家