Pancreatic cancer is one of the leading causes off cancer-related deaths globally. In Europe, this type of cancer has the lowest survival rate of all cancers. A majority of patients have unresectable or even metastatic disease. In addition, actual therapeutic options are not curative, and surgical treatment is associated with high post-operative morbidity and a lack of uniform translation of surgical success into long-term survival. Moreover, there is no screening for the general population which is recommended, and the overall poor prognosis in pancreatic cancer is related to late clinical detection. Therefore, early diagnosis and early treatment of pancreatic cancer are particularly critical. In this review, we summarize the most significant gaps and opportunities in the diagnosis and treatment of pancreatic cancer to emphasize need for improvement of early detection and the therapeutic efficacy of the available treatment for this cancer. Novel, inclusive, and intentional research is needed to produce improvements in pancreatic cancer in mm the world.
胰腺癌是全球癌症相关死亡的主要原因之一。在欧洲，该类型癌症在所有癌症中生存率最低。多数患者确诊时已无法手术切除，甚至已发生转移。此外，现有治疗方案无法实现根治性疗效，手术治疗伴随较高的术后并发症发生率，且手术成功并不总能转化为长期生存获益。更值得注意的是，目前尚无推荐适用于普通人群的筛查方案，胰腺癌整体预后不良与临床发现较晚密切相关。因此，胰腺癌的早期诊断与早期治疗尤为关键。本文综述了胰腺癌诊疗领域最显著的不足与机遇，旨在强调提升早期检测能力及现有治疗方案疗效的迫切需求。全球范围内亟需开展创新性、包容性和前瞻性的研究，以推动胰腺癌诊疗水平的实质性进步。
Gaps and Opportunities in the Diagnosis and Treatment of Pancreatic Cancer
肿瘤(癌症)患者之家