文章：

肺神经内分泌肿瘤新兴精准医疗策略研究

Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors

原文发布日期：25 November 2023

DOI: 10.3390/cancers15235575

类型: Article

开放获取: 是

英文摘要：

Well-differentiated lung neuroendocrine tumors (LNETs) are heterogeneous cancers that are increasing in incidence. Treatment options for LNETs have expanded in recent years, and our knowledge of the molecular subtypes has also advanced. Multidisciplinary teams have an established role in personalizing the best treatment for individual patients. Other precision medicine approaches for the treatment of LNETs have lagged behind those for non-small-cell lung cancer, with only rare actionable molecular alterations identified and few established predictive factors to guide therapy selection. However, as summarized in this review, there is increasing potential for personalized treatment of patients with LNETs. In particular, advances in radiotheragnostics may allow us to tailor the treatment of individual patients with NETs in the coming years. These advances may soon deliver the promise of more effective, less toxic treatments and better outcomes for patients with these increasingly common cancers.

摘要翻译： 

高分化肺神经内分泌肿瘤（LNETs）是一类具有异质性的癌症，其发病率正逐年上升。近年来针对LNETs的治疗方案不断拓展，对其分子亚型的认知也日益深入。多学科诊疗团队在制定个体化治疗方案中发挥着重要作用。相较于非小细胞肺癌，LNETs的其他精准医疗策略发展相对滞后，目前仅发现少数可干预的分子变异，且缺乏成熟的预测因子来指导治疗方案选择。但正如本综述所述，LNETs的个体化治疗正展现出日益广阔的前景。特别是放射诊疗学的进步，有望在未来数年内实现对神经内分泌肿瘤患者的精准个体化治疗。这些进展或将推动更高效、低毒的治疗方案，为这类日益常见的癌症患者带来更好的临床结局。

原文链接：

Emerging Precision Medicine Approaches for Lung Neuroendocrine Tumors