文章：

载脂蛋白在常见癌症中的作用：综述

The Role of Apolipoproteins in the Commonest Cancers: A Review

原文发布日期：24 November 2023

DOI: 10.3390/cancers15235565

类型: Article

开放获取: 是

英文摘要：

Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the onset of a variety of human cancers; however, the role of certain APOs in cancer development remains unknown. Based on recent work, we hypothesize that APOs might be involved in the onset of cancer, with a focus on the most common cancers, including breast, lung, gynecological, colorectal, thyroid, gastric, pancreatic, hepatic, and prostate cancers. This review will focus on the evidence supporting this hypothesis, the mechanisms linking APOs to the onset of cancer, and the potential clinical relevance of its various inhibitors.

摘要翻译： 

载脂蛋白（APOs）是血浆脂蛋白的关键结构成分，参与脂质代谢与运输。近期研究表明，载脂蛋白失调与多种人类癌症的发生存在关联，但特定载脂蛋白在癌症发展中的作用机制尚未明确。基于最新研究进展，我们提出载脂蛋白可能参与癌症发生的假说，重点关注乳腺癌、肺癌、妇科肿瘤、结直肠癌、甲状腺癌、胃癌、胰腺癌、肝癌及前列腺癌等常见癌症类型。本综述将系统阐述支持该假说的证据、载脂蛋白与癌症发生关联的分子机制，以及各类载脂蛋白抑制剂的潜在临床价值。

原文链接：

The Role of Apolipoproteins in the Commonest Cancers: A Review