文章：

爱泼斯坦-巴尔病毒相关间叶性肿瘤的临床病理学综述与进展

A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors

原文发布日期：24 November 2023

DOI: 10.3390/cancers15235563

类型: Article

开放获取: 是

英文摘要：

The Epstein–Barr virus (EBV) is associated with various tumor types, including nasopharyngeal carcinoma and lymphoproliferative disorders. While much is known about EBV-related epithelial and lymphoid tumors, there is a paucity of knowledge concerning EBV-associated mesenchymal tumors. This review aims to provide a comprehensive overview of EBV-associated mesenchymal tumors, encompassing their clinical features, pathological characteristics, pathophysiology, prognostic factors, and current treatment approaches. Through an extensive literature search using the PubMed database, we were able to identify three distinct EBV-associated mesenchymal tumors: EBV-associated smooth muscle tumors, inflammatory pseudotumor-like follicular dendritic cell sarcomas, and EBV-associated osteosarcomas. Although this review extensively explored the different aspects of these mesenchymal tumors, our comprehension of the underlying pathophysiology in this context is still incomplete. Therefore, we hope that this review paper will not only serve as a valuable repository of information but also serve as a catalyst for prospective in vitro and in vivo research studies to bridge the existing knowledge gap surrounding pathophysiology, ultimately making an important contribution to shaping future therapeutic approaches.

摘要翻译： 

爱泼斯坦-巴尔病毒（EBV）与多种肿瘤类型相关，包括鼻咽癌和淋巴增殖性疾病。尽管关于EBV相关的上皮性和淋巴性肿瘤已有较多研究，但关于EBV相关间叶性肿瘤的认识仍较为匮乏。本综述旨在全面概述EBV相关间叶性肿瘤，涵盖其临床特征、病理学特点、病理生理机制、预后因素及当前治疗方法。通过使用PubMed数据库进行广泛文献检索，我们识别出三种不同的EBV相关间叶性肿瘤：EBV相关平滑肌肿瘤、炎性假瘤样滤泡树突细胞肉瘤以及EBV相关骨肉瘤。尽管本综述深入探讨了这些间叶性肿瘤的多个方面，但我们对相关病理生理机制的理解仍不完整。因此，我们希望本文不仅能作为重要的信息资料库，更能推动前瞻性的体外与体内研究，以弥合当前在病理生理机制方面的认知空白，最终为未来治疗策略的制定做出重要贡献。

原文链接：

A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors