文章：

上尿路癌与膀胱尿路上皮癌的临床及生物学差异及其临床实践意义

Clinical and Biological Differences between Upper Tract Carcinoma and Bladder Urothelial Cancer, Including Implications for Clinical Practice

原文发布日期：23 November 2023

DOI: 10.3390/cancers15235558

类型: Article

开放获取: 是

英文摘要：

Upper tract urothelial carcinoma (UTUC) is a rare disease included, along with the much more frequent urothelial bladder cancer (BUC), in the family of urothelial carcinomas (UCs). However, while UTUCs and BUCs share several features, their epidemiological, clinical, pathological, and biological differences must be considered to establish an optimal therapeutic strategy. This review examines the clinical differences between UTUC and BUC, as well as the main results obtained by molecular screening of the two diseases. The findings of clinical trials, performed in peri-operative and metastatic settings and assessing systemic treatments in UC, are summarised. A comparison of the data obtained for UTUC and BUC suggests improved therapeutic approaches, both in regards to routine practice and future drug development.

摘要翻译： 

上尿路尿路上皮癌（UTUC）是一种罕见疾病，与更为常见的膀胱尿路上皮癌（BUC）同属尿路上皮癌（UC）家族。尽管UTUC与BUC具有诸多共同特征，但在制定最佳治疗策略时，必须考虑两者在流行病学、临床、病理及生物学方面的差异。本综述探讨了UTUC与BUC的临床差异，以及通过分子筛查对这两种疾病获得的主要研究成果。同时总结了在围手术期和转移性环境中评估UC全身性治疗的临床试验结果。通过对比UTUC与BUC的研究数据，为临床常规实践和未来药物研发提供了更优化的治疗策略方向。

原文链接：

Clinical and Biological Differences between Upper Tract Carcinoma and Bladder Urothelial Cancer, Including Implications for Clinical Practice