Oral squamous cell carcinoma (OSCC) is the most common oral cavity malignancy associated with multiple risk factors. In the last 14 years, oral dysbiosis has attracted the scientific community’s attention as a potential oncogenic factor, in parallel with the development of omics technologies that have revolutionized microbiological research. The present umbrella review aimed to investigate the oral microbiological content (bacilli, viruses, and fungi) of tissue and saliva samples from adult (>18 years) patients with OSCC. The secondary objective was to compare the oral microbiome of OSCC subjects with non-OSCC subjects. The study protocol was under the PRISMA statement and registered on PROSPERO (CRD42023448153). Data from 32 systematic reviews were extracted, qualitatively summarized, and analyzed using AMSTAR-2. An increase in oral bacteria of the phylum Fusobacteria, Proteobacteria, and Bacteroidetes and a decrease in Firmicutes and Actinobacteria were observed in OSCC patients. The increased bacterial genera were periodontopathogens. The most common viruses were EBV and HPV, especially the high-risk genotypes. Candida was the most studied oral fungus and was always increased in OSCC subjects. Further studies should investigate the possible carcinogenic mechanisms of oral microorganisms found increased in tissue samples and saliva from adult subjects with OSCC.
口腔鳞状细胞癌（OSCC）是最常见的口腔恶性肿瘤，其发生与多种风险因素相关。过去14年间，随着组学技术革命性地推动了微生物学研究，口腔菌群失调作为潜在致癌因素已引起科学界广泛关注。本伞状综述旨在探究成年（>18岁）OSCC患者组织与唾液样本中的口腔微生物组成（杆菌、病毒及真菌），次要目标为比较OSCC与非OSCC人群的口腔微生物组特征。研究方案遵循PRISMA声明并在PROSPERO平台注册（CRD42023448153）。通过AMSTAR-2工具对32篇系统综述进行数据提取、定性总结与分析。研究发现OSCC患者口腔中梭杆菌门、变形菌门及拟杆菌门细菌丰度上升，而厚壁菌门与放线菌门丰度下降。其中增多的细菌属多为牙周致病菌。最常见病毒为EB病毒和人乳头瘤病毒，尤以高危基因型为主。念珠菌属是研究最广泛的口腔真菌，在OSCC患者中持续呈现高检出率。未来研究应深入探讨OSCC成年患者组织与唾液中异常增殖的口腔微生物可能存在的致癌机制。
肿瘤(癌症)患者之家