文章：

新辅助治疗后直肠癌器官保留时代的临床反应评估工具

Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation

原文发布日期：22 November 2023

DOI: 10.3390/cancers15235535

类型: Article

开放获取: 是

英文摘要：

Local tumor response evaluation following neoadjuvant treatment(s) in rectal adenocarcinoma requires a multi-modality approach including physical and endoscopic evaluations, rectal protocoled MRI, and cross-sectional imaging. Clinical tumor response exists on a spectrum from complete clinical response (cCR), defined as the absence of clinical evidence of residual tumor, to near-complete response (nCR), which assumes a significant reduction in tumor burden but with increased uncertainty of residual microscopic disease, to incomplete clinical response (iCR), which incorporates all responses less than nCR that is not progressive disease. This article aims to review the clinical tools currently routinely available to evaluate treatment response and offers a potential management approach based on the extent of local tumor response.

摘要翻译： 

直肠腺癌新辅助治疗后局部肿瘤反应的评估需采用多模式方法，包括体格与内镜检查、直肠专用方案磁共振成像以及横断面影像学检查。临床肿瘤反应呈现连续谱系：从完全临床缓解（定义为无残留肿瘤的临床证据），到近完全缓解（指肿瘤负荷显著减少但残留微观病灶的不确定性增加），再到不完全临床缓解（涵盖所有未达近完全缓解标准但非疾病进展的反应状态）。本文旨在综述当前常规用于评估治疗反应的临床工具，并根据局部肿瘤反应程度提出潜在的管理策略。

原文链接：

Clinical Tools for Rectal Cancer Response Assessment following Neoadjuvant Treatment in the Era of Organ Preservation