Oxidative stress has been implicated in the development, proliferation, and metastasis of colorectal cancer, but few studies have considered how oxidative stress changes in relation to treatment response. In this study, we investigated whether the rate of change in reactive oxygen metabolite derivatives (d-ROM)—serum markers of oxidative stress—could predict treatment response in metastatic colorectal cancer. We enrolled 53 patients with metastatic colorectal cancer who were treated with 3 months of chemotherapy. We measured d-ROM levels and performed computed tomography before and after chemotherapy, and we examined the change in d-ROM levels for each anticancer treatment. Factors influencing the d-ROM ratio (post-treatment: pre-treatment levels) were examined using linear regression analysis. d-ROM levels decreased in patients showing a partial response (p< 0.001) and increased in those showing disease progression (p= 0.042). An increasing d-ROM ratio was associated with disease progression (regression coefficient: 0.416, 95% confidence interval: 0.279–0.555,p< 0.001). Our study indicates that d-ROM levels are useful markers of tumor progression and that the d-ROM ratio is useful for predicting treatment response in patients with metastatic colorectal cancer.
氧化应激与结直肠癌的发生、增殖及转移密切相关，但关于其随治疗反应如何变化的研究甚少。本研究旨在探讨活性氧代谢衍生物（d-ROM）——一种氧化应激血清标志物——的变化率能否预测转移性结直肠癌的治疗反应。我们纳入了53例接受3个月化疗的转移性结直肠癌患者，在化疗前后分别检测d-ROM水平并进行计算机断层扫描，同时分析每次抗癌治疗后d-ROM水平的变化。通过线性回归分析探讨影响d-ROM比值（治疗后水平与治疗前水平之比）的因素。结果显示，部分缓解患者的d-ROM水平显著下降（p<0.001），而疾病进展患者的d-ROM水平则升高（p=0.042）。d-ROM比值升高与疾病进展相关（回归系数：0.416，95%置信区间：0.279–0.555，p<0.001）。本研究表明，d-ROM水平可作为肿瘤进展的有效标志物，且d-ROM比值有助于预测转移性结直肠癌患者的治疗反应。
肿瘤(癌症)患者之家