文章：

蛋白质棕榈酰化在肿瘤细胞死亡中的研究进展

Advances of Protein Palmitoylation in Tumor Cell Deaths

原文发布日期：21 November 2023

DOI: 10.3390/cancers15235503

类型: Article

开放获取: 是

英文摘要：

In this comprehensive survey, we delve into the multifaceted role of palmitoylation across various cell death modalities in the oncological context, from its intricate correlations with tumorigenesis, steered by the Asp-His-His-Cys tetrapeptide motif (DHHC) family, to the counter-process of depalmitoylation mediated by enzymes like Palmitoyl protein thioesterase-1 (PPT1). Innovations in detection methodologies have paralleled our growing understanding, transitioning from rudimentary techniques to sophisticated modern methods. Central to our discourse are agents like Ezurpimtrostat (GNS561) and dimeric chloroquine (DC661), promising heralds in palmitoylation-targeted cancer therapy. Collectively, this review accentuates palmitoylation’s transformative potential in oncology, foreshadowing groundbreaking therapeutic strategies and deepening our molecular comprehension of cancer dynamics.

摘要翻译： 

在本综述中，我们深入探讨了棕榈酰化在肿瘤学背景下多种细胞死亡方式中的多维作用——从由Asp-His-His-Cys四肽基序（DHHC）家族调控的肿瘤发生复杂关联，到棕榈酰蛋白硫酯酶-1（PPT1）等酶介导的去棕榈酰化逆向过程。检测方法的创新与认知深化同步发展，从基础技术逐步演进至现代精密检测体系。以Ezurpimtrostat（GNS561）和二聚氯喹（DC661）为代表的靶向棕榈酰化治疗药物，正成为肿瘤治疗领域的重要突破方向。本综述系统阐述了棕榈酰化在肿瘤学中的变革性潜力，不仅预示了突破性治疗策略的发展前景，更深化了我们对癌症动态的分子层面理解。

原文链接：

Advances of Protein Palmitoylation in Tumor Cell Deaths